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Frontiers of Agriculture in China

ISSN 1673-7334

ISSN 1673-744X(Online)

CN 11-5729/S

Front. Agric. China    2008, Vol. 2 Issue (1) : 103-109     DOI: 10.1007/s11703-008-0004-8
Deletion of TTTTA in 5′UTR of goat gene and its distribution in different population groups and genetic effect on bodyweight at different ages
LI Xianglong1, ZHOU Rongyan1, ZHENG Guiru1, LI Lanhui1, LIU Zhengzhu2, GONG Yuanfang2
1.College of Animal Science and Technology, Agricultural University of Hebei; 2.Department of Animal Science, Hebei Normal University of Science & Technology;
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Abstract A total of 436 goat samples from twenty-six populations were scanned for single nucleotide polymorphisms (SNPs) in 5′UTR of goat MSTN gene using sequencing and the polymerase chain reaction technique combined with restriction enzyme fragment length polymorphism (PCR-RFLP). The deletion of TTTTA found in 5′UTR of goat MSTN gene was conserved in different species and might be a unique mutation in goats. The Foreign Group and the Boer Goat backcrossed offspring had the highest and smallest genetic diversity of this mutation respectively, and also with the smallest and highest heterozygosity deficiency respectively. The genetic diversity of this mutation for the South Group of Chinese indigenous goat breeds was higher than that of the North Group, and the South Group had the smaller heterozygosity deficiency than the North Group. The estimated marginal means based on the modified population marginal mean and pairwise comparison between significant pairs showed that there was a trend that genotype AA had a significant effect on body weight and size from birth to four-month old (P < 0.05 or P < 0.01). It could be inferred that the deletion of TTTTA in 5′UTR of goat MSTN gene had a significant effect on body weight and size.
Issue Date: 05 March 2008
 Cite this article:   
LI Xianglong,ZHOU Rongyan,ZHENG Guiru, et al. Deletion of TTTTA in 5′UTR of goat gene and its distribution in different population groups and genetic effect on bodyweight at different ages[J]. Front. Agric. China, 2008, 2(1): 103-109.
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