Strategies for enhancing DNA vaccine potency
by targeting antigen-presenting cells

doi:10.1007/s11703-009-0073-3

Front. Agric. China

2009, Vol. 3

Issue (4) : 478-485 https://doi.org/10.1007/s11703-009-0073-3

Research articles

Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells

Xingxing WANG¹,Fei ZHONG¹,Nan LI¹,Dongmei HAN¹,Sumin PAN¹,Xiujin LI²,

1.Department of Basic Veterinary Medicine, College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China; 2.Department of Biotechnology, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066064, China;

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Abstract The potency of DNA vaccines to stimulate the immune response, especially the T-cell immune response against viral infections and tumors, depends mainly on the ability of antigen-presenting cells to process and present DNA-encoded antigens. Targeting the specific antigen to antigen-presenting cells is believed to be a crucial step for eliciting the T-cell response. Many strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells have been developed. In this article, we generally introduce a T cell immune system and reviewe some strategies that recently develop for enhancing DNA vaccine potency.

Keywords DNA vaccine antigen presenting cells targeting immune response

Issue Date: 05 December 2009

Cite this article:

Xingxing WANG,Fei ZHONG,Nan LI, et al. Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells[J]. Front. Agric. China, 2009, 3(4): 478-485.

URL:

https://academic.hep.com.cn/fag/EN/10.1007/s11703-009-0073-3
https://academic.hep.com.cn/fag/EN/Y2009/V3/I4/478

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