Please wait a minute...
Shopping Cart Email List Chinese
Advanced Search Fig/Tab
Frontiers of Chemical Science and Engineering

ISSN 2095-0179

ISSN 2095-0187(Online)

CN 11-5981/TQ

Postal Subscription Code 80-969

2018 Impact Factor: 2.809

Featured Articles  |  Most Downloaded  |  Most Reading
Online Submission Subscribe to Our RSS Content Feed
Front Chem Sci Eng    2013, Vol. 7 Issue (1) : 116-122    https://doi.org/10.1007/s11705-013-1310-0
RESEARCH ARTICLE
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR(), Kaushlendra SHARMA
Birla Institute of Technology, Patna 800014, India
 Download: PDF(415 KB)   HTML
 Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract

Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy-g-PMA). Various grades of Psy-g-PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy-g-PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy-g-PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.
Keywords psyllium      acetyl salicylic acid      in-vitro drug release      swelling      biodegradation     
Corresponding Author(s): KUMAR Ranvijay,Email:ranvijay143@gmail.com   
Issue Date: 05 March 2013
 Cite this article:   
Ranvijay KUMAR,Kaushlendra SHARMA. Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems[J]. Front Chem Sci Eng, 2013, 7(1): 116-122.
 URL:  
https://academic.hep.com.cn/fcse/EN/10.1007/s11705-013-1310-0
https://academic.hep.com.cn/fcse/EN/Y2013/V7/I1/116
GradeWt. of psyllium /mgWt. of silver sulfate/mgAmount of PMA /molTime of irradiation/sGrafting/%
Gr. I1.01.50.17715035
Gr. II1.00.80.17718041
Gr. III1.01.50.17721045
Gr. IV1.01.00.17718047
Gr. V1.01.50.17718058
Tab.1  Synthesized grades of Psy--PMA
Fig.1  Schematic representation for ‘Microwave Assisted’ Synthesis of Psy--PMA
Fig.1  Schematic representation for ‘Microwave Assisted’ Synthesis of Psy--PMA
Fig.2  FTIR spectra of (a) psyllium and (b) Psy--PMA
Fig.2  FTIR spectra of (a) psyllium and (b) Psy--PMA
Fig.3  (a) Photograph of psyllium tablet before and after swelling. Swelling study in (b) acidic, (c) neutral and (d) basic media
Fig.3  (a) Photograph of psyllium tablet before and after swelling. Swelling study in (b) acidic, (c) neutral and (d) basic media
Fig.4  Percent swelling in acidic, neutral and basic media
Fig.4  Percent swelling in acidic, neutral and basic media
Fig.5  Weight loss of the Psy--PMA tablets after 15 days of the soil burial tests
Fig.5  Weight loss of the Psy--PMA tablets after 15 days of the soil burial tests
Fig.6  Drug release in acidic medium (pH 4) from drug loaded Psy--PMA tablets
Fig.6  Drug release in acidic medium (pH 4) from drug loaded Psy--PMA tablets
Fig.7  Drug release in neutral medium (pH 7) from drug loaded Psy--PMA tablets
Fig.7  Drug release in neutral medium (pH 7) from drug loaded Psy--PMA tablets
Fig.8  Drug release in basic medium (pH 9) from drug loaded Psy--PMA tablets
Fig.8  Drug release in basic medium (pH 9) from drug loaded Psy--PMA tablets
Fig.9  Proposed mechanism for drug release from Psy--PMA tablets on the basis of Fickian diffusion
Fig.9  Proposed mechanism for drug release from Psy--PMA tablets on the basis of Fickian diffusion
1 Camilia G. Miche, Demiana I N, Nesrine S E, Taha S E. Bioactive aqueous extract of Nigella sativa L. seed waste: formulation and evaluation. Journal of Chemical and Pharmaceutical Research , 2011, 3: 213-225
2 Wong T W. Chitosan and its use in design of insulin delivery system. Recent Patents on Drug Delivery & Formulation , 2009, 3(1): 8-25
doi: 10.2174/187221109787158346
3 Pal S, Sen G, Mishra S, Dey R K, Jha U. Carboxymethyl tamarind: synthesis, characterization and its application as novel drug-delivery agent. Journal of Applied Polymer Science , 2008, 110(1): 392-400
doi: 10.1002/app.28455
4 Gils P S, Ray D, Sahoo P K. Controlled release of doxofylline from biopolymer based hydrogels.American Journal of Biomedical Sciences, 2010, 2: 373-383
doi: 10.5099/aj100400373
5 Singh B, Pal L. Development of sterculia gum based wound dressings for use in drug delivery. European Polymer Journal , 2008, 44(10): 3222-3230
doi: 10.1016/j.eurpolymj.2008.07.013
6 Omidian H, Park K.Swelling agents and devices in oral drug delivery. Journal of Drug Delivery Science and Technology , 2008, 1-418 : 83-93
7 Singh B, Chauhan G S, Sharma D K, Kant A, Gupta I, Chauhan N.The release dynamics of model drugs from the psyllium and N-hydroxymethylacrylamide based hydrogels. International J Pharmaceutics , 2006, 1-4325 : 15-25
8 Singh B, Bala R. Design of dietary polysaccharide and binary monomer mixture of acrylamide and 2-acrylamido-2-methylpropane sulphonic acid based antiviral drug delivery devices. Chemical Engineering Research & Design , 2012, 90(3): 346-358
doi: 10.1016/j.cherd.2011.07.023
9 Singh B. Psyllium as therapeutic and drug delivery agent. International Journal of Pharmaceutics , 2007, 334(1-2): 1-14
doi: 10.1016/j.ijpharm.2007.01.028
10 Yasir M, Asif M, Bhattacharya A, Bajpai M. Development and evaluation of gastroretentive drug delivery system for theopylline using psyllium husk. International Journal of ChemTech Research, 2010, 2: 792-799
11 Mehmood M H, Aziz N, Ghayur M N, Gilani A H. Pharmacological basis for the medicinal use of psyllium husk (Ispaghula) in constipation and diarrhea. Digestive Diseases and Sciences , 2011, 56(5): 1460-1471
doi: 10.1007/s10620-010-1466-0
12 Kumar K, Kaith B S. Kaith1 B S. Psyllium and acrylic acid based polymeric networks synthesized under the influence of g-radiations for sustained release of fungicide. Fibers and Polymers , 2010, 11(2): 147-152
doi: 10.1007/s12221-010-0147-0
13 Peepas N A. Hydrogels and drug delivery. Current Opinion in Colloid & Interface Science , 1997, 2(5): 531-537
doi: 10.1016/S1359-0294(97)80103-3
14 Mittal H, Kaith B S, Jindal R. Synthesis, characterization and swelling behaviour of poly(acrylamide-comethacrylic acid) grafted Gum ghatti based superabsorbent hydrogels. Advances in Applied Science Research , 2010, 1: 56-66
15 Kumar R, Sharma K, Tiwary K P, Sen G.Polymethacrylic acid grafted plantago psyllium mucilage (Psy-g-PMA): a novel material for waste water treatment. App Water Sci
16 Kalsi P S. Spectroscopy of Organic Compounds. 5th ed. New Delhi: New Age International (P) Limited, 2002, 60-181
17 Sen G, Pal S. Microwave initiated synthesis of polyacrylamide grafted carboxymethylstarch (CMS-g-PAM): application as a novel matrix for sustained drug release. International Journal of Biological Macromolecules , 2009, 45(1): 48-55
doi: 10.1016/j.ijbiomac.2009.03.012
18 Moore D J, Palmer J C, Liu Y C, Roussel T J, Brennan J K, Gubbins K E. Slow and fast (Fickian) diffusion modes for argon confined in BPL activated carbon. Diffusion Fundamentals Org , 2009, 95: 1-4
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed