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Frontiers of Chemical Science and Engineering

ISSN 2095-0179

ISSN 2095-0187(Online)

CN 11-5981/TQ

Postal Subscription Code 80-969

2018 Impact Factor: 2.809

Front. Chem. Sci. Eng.    2014, Vol. 8 Issue (2) : 225-232    https://doi.org/10.1007/s11705-014-1429-7
REVIEW ARTICLE
Semi-solid materials for controlled release drug formulation: current status and future prospects
Michelle TRAN, Chun WANG()
Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA
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Abstract

Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

Keywords semi-solids      polymer      excipient      controlled release      drug delivery     
Corresponding Author(s): Chun WANG   
Issue Date: 22 May 2014
 Cite this article:   
Michelle TRAN,Chun WANG. Semi-solid materials for controlled release drug formulation: current status and future prospects[J]. Front. Chem. Sci. Eng., 2014, 8(2): 225-232.
 URL:  
https://academic.hep.com.cn/fcse/EN/10.1007/s11705-014-1429-7
https://academic.hep.com.cn/fcse/EN/Y2014/V8/I2/225
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