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Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar |
G. Usha RANI,Kartick Prasad DEY,Srijita BHARTI,Sumit MISHRA( ) |
| Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India |
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Abstract The utilization of poly (2-hydroxyethylmethacrylate) grafted agar (Ag-g-P(HEMA)) as a matrix for the controlled release of 5-aminosalicylic acid was investigated. Grafted copolymers of 2-hydroxyethylmethacrylate (HEMA) monomers on agar were synthesized by microwave assisted method. In vitro drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting vs. t50 (the time taken for release of 50% of the enclosed drug) value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P(HEMA) appears to be a useful matrix for controlled release.
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| Keywords
agar
controlled drug release
5-Amino salicylic acid
poly(2-hydroxyethylmethacrylate) grafted agar
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Corresponding Author(s):
Sumit MISHRA
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Online First Date: 11 December 2014
Issue Date: 14 January 2015
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