Engineering platelet-mimicking drug delivery vehicles

doi:10.1007/s11705-017-1614-6

Front. Chem. Sci. Eng.

2017, Vol. 11

Issue (4) : 624-632 https://doi.org/10.1007/s11705-017-1614-6

REVIEW ARTICLE

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu^1,², Hunter N. Bomba^1,², Zhen Gu^1,^2,³(

)

¹. Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, NC 27695, USA
². Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA
³. Department of Medicine, University of North Carolina School of Medicine, NC 27599, USA

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Abstract

Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

Keywords drug delivery platelets nanomedicine bio-inspired biomimetic

Corresponding Author(s): Zhen Gu

Online First Date: 15 February 2017 Issue Date: 06 November 2017

Cite this article:

Quanyin Hu,Hunter N. Bomba,Zhen Gu. Engineering platelet-mimicking drug delivery vehicles[J]. Front. Chem. Sci. Eng., 2017, 11(4): 624-632.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-017-1614-6
https://academic.hep.com.cn/fcse/EN/Y2017/V11/I4/624

Fig.1 Different strategies of platelet-mimicking drug delivery system. (A) Platelet structure-mimicry includes discoid shape and spiny surface mimicking; (B) platelet membrane is purified and coated on the surface of polymeric nanoparticle

Fig.2 Schematic illustration of fabrication process of nanohair decorated microspheres. Reprinted with permission from Ref. 29

Fig.3 (A) The structure of deformable platelet-like particle with H6 sdFvs; (B) AFM images of inactive PLP and shape-changed PLP. Reprinted with permission of [33]; (C) The fabrication process of platelet-like particle decorated with collagen-binding peptide, the von Willebrand Factor binding peptide, and the linear fibrinogen-mimetic peptide. Reprinted with permission from Ref. 35

Fig.4 Schematic representation of the development of platelet mimicking particle. (A) The main component of plate-like particles; (B) the fabrication process of the synthetic platelet-like particle; (C) the SEM images of polymeric particles, synthetic platelet-mimicking particle, and natural platelet (from left to right). Reprinted with permission from Ref. 34

Fig.5 Schematic of design of drug-loaded PM-NV for targeting and sequential delivery of TRAIL and Dox. Reprinted with permission from Ref. 48

Fig.6 Schematic illustration of the platelet membrane-coated silica particles. Reprinted with permission of [53]

Fig.7 Schematic illustration of tPA-conjugated, Ald-functionalized and bortezomib-loaded PM-NP for MM and thrombus treatment. (A) The structure of tPA-Ald-PM-NP; (B) Sequentially targeting of tPA-Ald-PM-NP to bone microenvironment and MM cells; (C) Targeting and dissolution of thrombus. Reprinted with permission of [54]

Fig.8 Schematic design of the platelet membrane-cloaked nanoparticles for immunocompatibility, subendothelium binding, and pathogen adhesion. Reprinted with permission from Ref. 56

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