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Frontiers of Chemical Science and Engineering

ISSN 2095-0179

ISSN 2095-0187(Online)

CN 11-5981/TQ

Postal Subscription Code 80-969

2018 Impact Factor: 2.809

Front. Chem. Sci. Eng.    2014, Vol. 8 Issue (2) : 188-196     DOI: 10.1007/s11705-014-1414-1
Modification of polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet adhesion
Jing YANG1,Juan LV1,Bin GAO1,Li ZHANG1,Dazhi YANG1,Changcan SHI1,Jintang GUO1,2,Wenzhong LI4,*(),Yakai FENG1,2,3,*()
1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
2. Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Tianjin 300072, China
3. Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, China
4. University of Rostock, Department of Cardiac Surgery, Reference & Translation Center for Cardiac Stem Cell Therapy, Schillingallee 69, D-18057 Rostock, Germany
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Poly(ethylene glycol) monoacrylate (PEGMA) is grafted onto polycarbonateurethane (PCU) surface via ultraviolet initiated photopolymerization. The hydroxyl groups of poly(PEGMA) on the surface react with one NCO group of isophorone diisocyanate (IPDI) and another NCO group of IPDI is then hydrolyzed to form amino terminal group, which is further grafted with phosphorylcholine glyceraldehyde to establish a biocompatible hydrophilic structure on the surface. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the successful grafting of both PEG and phosphorylcholine functional groups on the surface. The decrease of the water contact angle for the modified film is caused by synergic effect of PEG and phosphorylcholine, which both have the high hydrophilicity. Furthermore, the number of platelets adhered is relative low on the synergetically modified PCU film compared with the PCU film modified only by poly(PEGMA). Our synergic modification method using both PEG and phosphorylcholine may be applied in surface modification of blood-contacting biomaterials and some relevant devices.

Keywords poly(ethylene glycol) monoacrylate      phosphorylcholine      polycarbonateurethane      surface modification      anti-platelet adhesion      biomaterials     
Corresponding Authors: Wenzhong LI   
Issue Date: 22 May 2014
URL:     OR
Fig.1  Schematic illustration of grafting PEGMA and PCGA onto PCU surface
Fig.2  Reaction of -N=C=O with H2O to form amino group on the film surface
Fig.3  FT-IR spectra of blank PCU, PCU-PEGMA, PCU-PEGMA-NH2 and PCU-PEGMA-PC films
Fig.4  XPS spectra of blank PCU, PCU-PEGMA and PCU-PEGMA-PC films
Material IDAtomic concentration /%O : C /%
Blank PCU77.920.
Tab.1  Surface elemental composition of the blank and modified PCU films by XPS
Fig.5  Water contact angles of blank PCU, PCU-PEGMA, PCU-PEGMA-NH2 and PCU-PEGMA-PC films
Fig.6  SEM images of adhered platelets on (A) blank PCU, (B) PCU-PEGMA and (C) PCU-PEGMA-PC films
Fig.7  Quantification of platelets adhered on the blank PCU, PCU-PEGMA and PCU-PEGMA-PC films
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