This paper develops an empirical model to test the spatial spillover effects of transport infrastructure on economic growth. It uses spatial econometric techniques and provincial panel data of China from 1993 to 2004 to analyze the contribution of transport infrastructure to the economic growth of local province and its spatial spillover effects on the economic growth of other provinces. The main findings include: (1) Transport infrastructure and economic growth of China show an evident pattern of spatial clustering. They largely congregate in developed eastern coastal regions, forming a gradient gradually diminishing from east to west. (2) Output elasticity of local transport infrastructure is 0.106, between the values calculated by early researchers with time series data and panel data. (3) Spatial output spillovers from transport infrastructure are largely positive, but evidences of negative spatial spillovers are also found with population density spatial weights matrix model.