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Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature |
Karimeh Haghani1, Pouyan Asadi2, Gholamreza Taheripak3, Ali Noori-Zadeh4, Shahram Darabi5, Salar Bakhtiyari1() |
1. Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran 2. Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran 3. Department of Clinical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 4. Department of Clinical Biochemistry, Faculty of Paramedicine, Ilam University of Medical Sciences, Ilam, Iran 5. Cellular and Molecular Research Center, Qazvin University of Medical Science, Qazvin, Iran |
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Abstract BACKGROUND: Diabetes mellitus (DM) is one of the most prevalent chronic diseases, and its prevalence continues to increase globally. The impact of mitochondrial dysfunction and lipid metabolism on diabetes mellitus and insulin resistance (IR) has been implicated in several previous reports; however, the results of studies are confusing despite four decades of study. METHODS/RESULTS: This review has evaluated updated understanding of the role of mitochondrial dysfunction and lipid metabolism on type 2 diabetes, and found that mitochondrial dysfunction and lipid metabolism disorder induce the dysregulation of liver and pancreatic beta cells, insulin resistance, and type 2 diabetes. CONCLUSION: Mitochondrial dysfunction and lipid metabolism induce metabolic dysregulation and finally increasing the possibility of diabetes.
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Keywords
Insulin resistance
Type 2 diabetes
Mitochondrial dysfunction
Lipid metabolism
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Corresponding Author(s):
Salar Bakhtiyari
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Online First Date: 26 October 2018
Issue Date: 30 November 2018
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