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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2007, Vol. 1 Issue (4) : 423-428     DOI: 10.1007/s11684-007-0083-6
The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter baumannii
YANG Li1, HAN Lizhong2, SUN Jingyong2, NI Yuxing2, YU Yunsong3
1.Nosocomial Infection Control Office of Ruijin Hospital, College of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China; 2.Department of Clinical Microbiology, Ruijin Hospital, College of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China; 3.Department of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310002, China;
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Abstract  This paper reported the epidemiology of the colistin-only-sensitive Acinetobacter baumannii(COS-AB) in a tertiary teaching hospital in China. We analyzed the clinical data of 136 COS-AB isolates from June 2004 to May 2005 and collected 66 A.baumannii isolates in which 33 strains were COS-AB, and the rest were non-COS-AB. Random amplified polymorphic DNA (RAPD) analysis (primer ERIC2 and 272) showed that all COS-AB were identical, while pulsed-field gel electrophotesis (PFGE) analysis showed two separate genotypes of these COS-AB which were distinctly different from that of non-COS-AB. The COS-AB from burn wards showed the identical PFGE pattern which was distinguished from the genotype of COS-AB in other departments, mainly surgical systems. The cross-infection was severe and strict methods of disinfection and sterilization should be implemented. Meanwhile, the epidemiology of COS-AB in environment and patients should be closely monitored. The PFGE analysis is a reliable method of A.baumannii typing.
Issue Date: 05 December 2007
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