|
|
|
A belated revelation: from gastroesophageal reflux
derived asthma to laryngotracheal irritation even spasm |
| WANG Zhonggao |
| Center for GER, Second Artillery General Hospital, Clinical Research College, Beijing Normal University；Department of Cardiothoracic Vascular Surgery, China Center for GER, Xuanwu Hospital, Capital Medical University |
|
|
|
|
Abstract The author has been inspired by the Global Evidence-Based Consensus for gastroesophageal reflux (GER), which put forward four extra-esophageal syndromes: reflux cough syndrome, reflux laryngitis syndrome, reflux dental erosion syndrome and the reflux asthma syndrome. The author himself happened to receive five emergency rescue treatments following apparent “bronchial asthma”, which was to be diagnosed as GER at his own insistence. PPI resulted in some relief. After being rescued again from suffocation, he had a fundaplication, which was performed at the Englewood Hospital & Medical Center, Englewood, USA in March 2006. The procedure immediately cleared up his “asthma”. A month later he brought forth a Center for GER in an army hospital in Beijing, China. Up to now, 601 patients with mainly respiratory distress (84%) were treated by Stretta Radiofrequency, 58 by surgery and more by PPI. The GER Center is now complete with a ward. GER patients with respiratory distresses turned out to fare better than those with acid regurgitation. A nozzle-shaped pharynx was found in patients with the reflux. Animal study revealed that the refluxate entered into trachea and even lungs. Gradually a hypothesis of a gastro-oesophago-laryngo-tracheal reflux took shape.Our modest effort to treat GER-derived respiratory distresses has got off to an encouraging start amid relative shortage of experience and facilities. We would like to share two thoughts with scholars and experts at home and abroad:1. The GER-derived asthma is not asthma, but GER pure and simple;2. The pathogenesis of “asthma” is not asthma, but laryngotracheal irritation/spasm and its sequence.
|
|
Issue Date: 05 June 2008
|
|
| 1 |
Harding S M Gastroesophagealreflux as an asthma trigger: acid stressChest 2004 126(5)13981399.
doi:10.1378/chest.126.5.1398
|
| 2 |
Vakil N van Zanten S V Kahrilas P Dent J Jones R Global Consensus Group. The Montreal definitionand classification of gastroesophageal reflux disease: A global evidence-basedconsensusAm J Gastroenterol 2006 101(8)19001920.
doi:10.1111/j.1572‐0241.2006.00630.x
|
| 3 |
Zhu L Ma H Zhong N Symptom correlation between asthma and grastroesophagealrefluxZhonghua Jie He He Hu Xi Za Zhi 2002 25(12)739743(in Chinese)
|
| 4 |
Wang Z G Itis gastroesophageal reflux disease, but not asthma: a case reportChin Med Sci J 2006 21(3)189193
|
| 5 |
Wang Z G Kotwal M R Ibrahim I M et al.GERD, not asthma: a case reportJ Gastroenterol Hepatol 2006 21(Suppl 6)112
|
| 6 |
Wang Z G NotGERD, but asthma: case reportFront MedChina 2007 2(1)15
|
| 7 |
Wang Z G Wu J M Liu J J et al.Stretta frequency for the treatment of GERD withthe respiratory problem mainly: experience of 180 patientsJ Gastroenterol Hepatol 2007 22(Suppl 2)A139
|
| 8 |
Wang Z G Chen X Wu J M et al.Operative mean and outcomes of various proceduresfor patients with gastroesophageal reflux disease (GERD) and severerespiratory problemsJ Gastroenterol Hepatol 2007 22(Suppl 2)A153
|
| 9 |
Wang Z G Chen X Han B Liu J J Li Z Yan J H Gong Y Wu J M Li M Y Shui P Pneumothorax secondary to gastro-oesophageal reflux-relatedintractable asthmaLin Chuang Wu Zhen WuZhi 2006 19(11)89(in Chinese)
|
| 10 |
Wang Z G Wu J M Liu J J Wang L Y Chen X Gong Y Bei J Dong Y Y Xu H Hu Y H Correct diagnosis and treatment in a patientwith gastroesphago-larygotracheal syndrome combined svere lung damageLin Chuang Wu Zhen Wu Zhi 2007 20(9)12(in Chinese)
|
| 11 |
Wang Z G Lai Y G Wu J M Gong Y Hu Y H Li C M Evidencefrom preliminary animal study for gastroesophgo-laryngotracheal refluxLin Chuang Wu Zhen Wu Zhi 2007 20(12)12(in Chinese)
|
| 12 |
Wang Z G Liu J J Chen X Wu J M Wang L M Gong Y Bai J Dong Y Y Hu Y H Lai Y G Discovery and denomination of gastroesphago-laryngotrachealsyndrome(GELTS) - summing-up on treating 200 GERD patients with strettaradiofrequencyLin Chuang Wu Zhen Wu Zhi 2007 20(5)14(in Chinese)
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
