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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med Chin    2009, Vol. 3 Issue (1) : 41-44     DOI: 10.1007/s11684-009-0009-6
RESEARCH ARTCILE |
Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters
Fen LAN, Shengdao XIONG(), Weining XIONG, Guopeng XU, Xiaoxia LU
Department of Respiratory Medicine, Key Laboratory of Pulmonary Diseases of Ministry of Health of China, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430300, China
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Abstract  

This study aims to research the expression of spleen tyrosine kinase (Syk) in non-small cell lung cancer (NSCLC) and the relationship between Syk and clinicopathologic factors and p53. Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLC (23 cases of lung squamous cell cancer, 16 cases of lung adenocarcinoma) and tumor-surrounding normal lung tissues. The positive rate of Syk was 46.15% (18/39) and 100% (39/39) in NSCLC and tumor-surrounding normal lung tissues, respectively. The expression level of Syk in NSCLC was significantly lower than that in tumor-surrounding normal lung tissues (P = 0.000). The Syk expression was positively correlated withthe p53 expression in NSCLC specimens (P = 0.025). There was no significant association between Syk expression and lymph node metastasis, differentiation degree, tumor size and tumor node metastasis (TNM). The present study demonstrated that Syk was aberrantly expressed in the NSCLC and might have a significant impact on tumor growth and progression.

Keywords Syk kinase      carcinoma, non-small-cell lung      tumor suppressor protein p53     
Corresponding Authors: XIONG Shengdao,Email:sdxiong@tjh.tjmu.edu.cn   
Issue Date: 05 March 2009
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-009-0009-6     OR     http://academic.hep.com.cn/fmd/EN/Y2009/V3/I1/41
Fig.1  Expression of Syk protein in lung adenocarcinoma and lung squamous cell cancer (DAB, × 200). (a) negative expression of Syk protein in lung adenocarcinoma; (b) positive expression of Syk protein in lung adenocarcinoma; (c) negative expression of Syk protein in lung squamous cell cancer; (d) positive expression of Syk protein in lung squamous cell cancer.
groupnSyk
-+positive rate/%P value
lymph node metastasis
No1971263.20.056
Yes2014630.0
differentiation degree
poor-undifferentiated138538.50.734
well-moderate26131350.0
tumor size
≤ 3 cm83562.50.432
> 3 cm31181341.9
TNM
I + II2181361.90.054
III + IV1813527.8
Tab.1  Relationship between the expression of Syk and clinical parameters in lung cancer
Fig.2  Expression of p53 protein in (a) lung adenocarcinoma; (b) lung squamous cell cancer (DAB, × 200)
groupnSyk
-+positive rate/%P value
p53 (-)2316730.40.025
p53 (+)1651168.8
Tab.2  Correlation between Syk and p53 protein in lung cancer
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