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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med Chin    2009, Vol. 3 Issue (1) : 96-99     DOI: 10.1007/s11684-009-0014-9
RESEARCH ARTICLE |
Effect of Ca2+ complexation on oxygen partial pressure in the urinary bladder meridian of goats
Qi WANG1(), Hongzhi JIANG1, Shengli CHEN2, Mingmin ZHANG3, Mingxing DING4, Esheng KONG5, Guangying HUANG1
1. Institute of Traditional Chinese & Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2. Department of Pharmaceutical Analysis, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China; 3. Department of Traditional Chinese & Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 4. College of Animal Breeding and Veterinary, Huazhong Agricultural University, Wuhan 430070, China; 5. Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract  

The aim of this paper was to explore the relationship between energy metabolism and the meridian phenomenon. The manner of change of oxygen partial pressure in acupoints and no-acupoints of the urinary bladder meridian of goats was observed with a needle-type tissue oxygen tension sensor after the acupuncture effect was blocked by Ca2+ complexation with ethylenediamine tetraacetic acid (EDTA)-Na2. The results showed that: (1) the concentration of calcium ion in urinary bladder meridian acupoints was higher than that in no-acupoints (P<0.01 or P<0.05); (2) the tissue oxygen tension in urinary bladder meridian acupoints was higher than that in no-acupoints (P<0.01); (3) the oxygen partial pressure in acupoints decreased significantly after injection with EDTA-Na2, compared with injection of either normal sodium or nothing (P<0.01); (4) the oxygen partial pressure in acupoints was higher than that in no-acupoints after EDTA-Na2 injection (P<0.01). Acupuncture could reduce oxygen partial pressure in acupoints by regulating microcirculation and increasing metabolic levels.

Keywords oxygen partial pressure      biosensor      calcium channels      acupoint     
Corresponding Authors: WANG Qi,Email:wangqixlp@hotmail.com   
Issue Date: 05 March 2009
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-009-0014-9     OR     http://academic.hep.com.cn/fmd/EN/Y2009/V3/I1/96
groupncalcium ion electric potential valueP value
Ganshu10-42.73±7.832*0.0167
Ganshu beside10-51.45±6.912
Dachangshu10-38.73±8.164**0.0037
Dachangshu beside10-50.51±7.62
Guanyuanshu10-44.43±8.192*0.0331
Guanyuanshu beside10-53.36±9.093
Tab.1  The calcium ion electric potential value in urinary bladder meridian acupoints and no-acupointsunit: mV
groupGanshu (n=8)Ganshu beside (n=8)Guanyuanshu (n=8)Guanyuanshu beside (n=8)
injected with nothing 5.96±0.573*3.93±0.6925.81±0.525*3.70±0.773
injected with normal sodium 6.10±0.573*3.93±0.7235.76±0.510*3.70±0.844
injected with EDTA-Na27.85±1.262*?5.31±1.609?7.80±0.913*?4.74±0.588?
Tab.2  The tissue oxygen tension in urinary bladder meridian acupoints and in no-acupointsunit: kpa
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[1] Jisheng Han, Cailian Cui, Liuzhen Wu. Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine[J]. Front Med, 2011, 5(2): 141-150.
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