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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med Chin    2009, Vol. 3 Issue (2) : 227-229     DOI: 10.1007/s11684-009-0035-4
RESEARCH ARTICLE |
A new thinprep cytologic test of cervical cells and its application
Xiaojun ZHAO, Jingjuan WEI, Rong WANG, Yajun GU, Yunde LIU()
Clinical Laboratory Science Department of Tianjin Medical University, Tianjin 300203, China
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Abstract  

In order to improve the quality of routine cervical smears, we investigated the new Thinprep cytologic test (TCT) for cervical cells. In this study, 100 women who were enrolled were randomly divided into two groups. In one group, the TCT for cervical cells was applied (TCT group), and in the other group routine cervical smear was used. In addition, the cells in the TCT group were screened by double sifters, and centrifuged using a separation medium so as to eliminate mucus, inflammatory cells and blood cells. According to the cell distribution and the thickness of the smear, the results were assigned to three groups, including satisfactory smears, less satisfactory smears and unsatisfactory smears. The TCT had a higher satisfactory rate (98%) compared to the routine cervical smear (32%) (P<0.01), indicating the TCT was superior to the routine cervical smear. It is concluded that the TCT is more acceptable. Meanwhile, in comparison to the routine cervical smear, the TCT for cervical cells has 5 advantages which can greatly increase the cytological accuracy.

Keywords thinprep cytologic test      cervical cells      Papanicolaou smear     
Corresponding Authors: LIU Yunde,Email:yundeliu@126.com   
Issue Date: 05 June 2009
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-009-0035-4     OR     http://academic.hep.com.cn/fmd/EN/Y2009/V3/I2/227
calcium propionatepotassium sorbatesodium benzoatecomplex compound
Cell destruction ++c+b+++d+b
bacteria proliferation++c++c++c+/-a
Tab.1  Results of cervical cells preserved for 3 weeks with 4 kinds of preserving fluid
cell distortion and destructioncell adhesion after centrifugationcell superpositioncell enrichmentimpurity separation in mucus
acids++c+++d+b++c+b
salts-a-a++c+b-a
saccharide-a-a-a+++d++c
mucussolvent++c+b+b++c-a
alcohols+b-a+++d++c+b
Tab.2  Comparison of the effectiveness of 5 kinds of separating medium
groupssatisfaction (n)less satisfaction (n)dissatisfaction (n)satisfactory rateP value
11629532%&lt;0.01
2482098%
Tab.3  Comparison of the effectiveness between groups 2 and 1
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