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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2009, Vol. 3 Issue (3) : 330-335     DOI: 10.1007/s11684-009-0051-4
Research articles |
Protective effects of nicotine on gamma-aminobutyric acid neurons and dopaminergic neurons in mice with Parkinson disease
Lei FU MD 1, Dezheng GONG BM 1, Yan PENG 1, Dongmei WANG BM 1, Hong XU 1, Yue LI MD 2, Dengqin YU BS 2, Yanhui FENG MD 2, Shengming YIN PhD 2, Jin GONG 3, Yiping SUN PhD 4,
1.Lab of Physiological Function, College of Basic Medicine, Dalian Medical University, Dalian 116044, China; 2.Department of Physiology, College of Basic Medicine, Dalian Medical University, Dalian 116044, China; 3.Department of Anatomy, College of Basic Medicine, Dalian Medical University, Dalian 116044, China; 4.Lab of Physiological Function, College of Basic Medicine, Dalian Medical University, Dalian 116044, China;Department of Physiology, College of Basic Medicine, Dalian Medical University, Dalian 116044, China;
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Abstract  This study aimed to investigate the protective effect of nicotine on dopaminergic neurons and its mechanisms in mice with Parkinson disease (PD) induced by 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP). C57BL/6J mice were injected with MPTP for 8 days to establish a PD model. Nicotine was given for 10 days in the nicotine therapeutic group. Animals were examined behaviorally with the pole test and traction test. Tyrosine hydroxylase (TH) and γ-aminobutyric acid (GABA) were determined by using the immunocytochemistry (ICC) method. The ultrastructural changes of the caudate nucleus (CN) were observed under electron microscopy. The results showed that pretreatment with nicotine could improve the dyskinesia of PD mice markedly. Simultaneously, TH-positive (P < 0.01) neurons and GABA-positive (P < 0.05) neurons in the nicotine therapeutic group were significantly more than those in the model group. The ultrastructural injury of the nicotine therapeutic group was also ameliorated. Nicotine has protective effects on the γ-aminobutyric acid neurons and dopaminergic neurons in the MPTP-treated mice.
Keywords Parkinson disease      nicotine      dopaminergic neuron      gamma-aminobutyric acid neuron      
Issue Date: 05 September 2009
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-009-0051-4     OR     http://academic.hep.com.cn/fmd/EN/Y2009/V3/I3/330
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