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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2009, Vol. 3 Issue (3) : 336-340     DOI: 10.1007/s11684-009-0053-2
Research articles |
Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription
Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,
Department of Clinical Laboratory Sciences, Tianjin Medical University, Tianjin 300203, China;
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Abstract  Lanthanum salt is a prescription drug, but its underlying functions and mechanisms are not fully understood currently. To explore the potential therapeutic value of lanthanum chloride, cytotoxicity test was applied to investigate its effects on cell proliferation. Furthermore, we observed its influence on pro-oncogene c-met by reverse transcription polymerase chain reaction (RT-PCR). In MCF-7 cell line, lanthanum chloride repressed cell proliferation at high concentration but had no significant inhibition effect on cell growth at low concentration. However, we observed that lanthanum chloride repressed c-met transcription at a low concentration. This may suggest that lanthanum chloride is a potent drug to inhibit the high expression of c-met in carcinoma cells and play a clue for inhibiting the growth and invasion of tumor.
Keywords proliferation      c-met      invasion      lanthanum chloride      
Issue Date: 05 September 2009
URL:     OR
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