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Effect of compound Sophorae Flavescentis Jiechangrong
capsule on expression of NF-κB p65 and STAT6 in the intestinal
mucosa of patients with ulcerative colitis |
| Heng FAN MD,Jia ZHAO MM,Lin SHEN BM,Qing TANG MD,Zhexin SHOU MM,Li LIANG BM,Yi LIAO BM,Xiaoyan CHEN BM, |
| Department of Traditional
Chinese and Western Medicine, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan 430022, China; |
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Abstract The effects of compound Sophorae Flavescentis Jiechangrong capsule (CSFJC) on the expression of nuclear factor-κB p65 (NF-κB p65) and signal transducer and activator of transcription 6 (STAT6) in the intestinal mucosa of patients with ulcerative colitis and the possible mechanism were investigated. Eighteen patients with ulcerative colitis were randomly divided into a traditional Chinese medicine (TCM) group (n = 11) treated by CSFJC and a western medicine (WM) group (n = 7) treated by Sulfasalazine tablets. The treatment duration lasted eight weeks. Before and after the treatment, the symptoms and the physical signs were observed, and the routine stool test, the colonoscopy, and pathological examination were performed in the two groups. The expression levels of NF-κBp65 and STAT6 were detected by using immunohistochemistry. The results showed that the total effective rate of the curative effectiveness in TCM and WM groups was 100% and 71.4%, respectively, and the total effective rate of colonic mucosa lesion in TCM and WM groups was 90.9% and 71.4%, respectively, with the differences being significant (all P < 0.05). The total effective rate of syndromes of damp-heat blocking according to the TCM in TCM and WM groups was 90.9% and 71.4%, respectively. After the treatment, the expression of NF-κB p65 and STAT6 in the two groups was decreased, and the decrease of NF-κB p65 and STAT6 expression in TCM group was more significant than in WM group (P < 0.05). It was concluded that CSFJC can inhibit the activation and expression of NF-κB p65 and STAT6 in the intestinal mucosa of patients with ulcerative colitis, which is a possible mechanism for CSFJC treating ulcerative colitis.
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| Keywords
colitis, ulcerative
compound Sophorae Flavescentis Jiechangrong capsule
nuclear factor-κB p65 (NF-κB p65)
signal transducer and activator of transcription 6 (STAT6)
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Issue Date: 05 December 2009
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