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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2009, Vol. 3 Issue (4) : 475-479     DOI: 10.1007/s11684-009-0086-6
Research articles |
Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis
Rui ZHU MD,Heng FAN MD,Lin SHEN MD,Jianguo LIU BD,Jia ZHAO MM,
Department of Traditional Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;
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Abstract  The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κB (NF-κB) in the colonic mucosa of patients with ulcerative colitis (UC) was examined. Real-time polymerase chain reaction and immunohistochemistry were used to detect the expression of STAT6 and NF-κB p65 at both mRNA and protein levels in the colonic mucosa of patients with UC and healthy volunteers. The results showed that the expression levels of STAT6 and NFκB p65 in the colonic mucosa of patients with UC were significantly higher than in normal controls at both mRNA and protein levels. These data suggest that STAT6 and NFκB p65 perhaps play an important role in the pathogenesis of UC and underscore the potential value of anti-UC strategies in the clinical management of this disease.
Keywords ulcerative colitis      signal transducer and activator of transcription 6 (STAT6)      nuclear factor-κB p65 (NF-κB p65)      
Issue Date: 05 December 2009
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-009-0086-6     OR     http://academic.hep.com.cn/fmd/EN/Y2009/V3/I4/475
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