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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2010, Vol. 4 Issue (1) : 29-35     DOI: 10.1007/s11684-010-0012-y
Research articles |
Clinical and genetic risk factors for venous thromboembolism in Chinese population
Chen WANG PhD, MD1,Zhen-Guo ZHAI PhD, MD1,Ying H. SHEN PhD, MD2,Lan ZHAO PhD, MD3,
1.Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; 2.Baylor College of Medicine, Houston, TX 77004, USA; 3.Department of Experimental Medicine and Toxicology, Hammersmith Hospital, Imperial College London, London W12 0NN, UK;
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Abstract  Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, carries significant mortality and morbidity. The most important and effective way to reduce VTE incidence is to identify the patients at risk and give necessary prevention. VTE is a multifactorial and complicated disorder. Major risk factors for VTE include surgery and trauma, acute medical illness, active cancer and pregnancy. Genetic factors increase susceptibility to the disease and are useful in predicting the development of VTE. Gene-gene and gene-environment interactions alter and magnify the clinical picture in this disorder. This brief review summarizes some selected clinical and genetic risk factors for VTE based on the current research in China.
Keywords risk factor      stroke      prothrombin      plasminogen activator inhibitor type-1      polymorphism      thrombophilia      biomarker      
Issue Date: 05 March 2010
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-010-0012-y     OR     http://academic.hep.com.cn/fmd/EN/Y2010/V4/I1/29
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