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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2010, Vol. 4 Issue (1) : 59-66    https://doi.org/10.1007/s11684-010-0015-8
Research articles
Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation
Dai-Hai YU PhD1,Jian-Feng HUANG MD1,Ji-Chun CHEN MS1,Jie CAO MS1,Shu-Feng CHEN PhD1,Dong-Feng GU MD, PhD, for the GenSalt Collaborative Research Group1,De-Pei LIU PhD2,Lai-Yuan WANG PhD3,Jing CHEN MD, MSc4,Jiang HE MD, PhD4,Cashell E. JAQUISH PhD5,Dabeeru C. RAO PhD6,Charles GU PhD6,James E. HIXSON PhD7,Chung-Shiuan CHEN MS8,Paul K. WHELTON MD, MSc9,
1.Department of Evidence-based Medicine and Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; 2.Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; 3.Department of Evidence-based Medicine and Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;Chinese National Human Genome Center at Beijing, Beijing 100176, China; 4.Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA;Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA; 5.National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA; 6.Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; 7.University of Texas School of Public Health, Houston, TX 77030, USA; 8.Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA; 9.Loyola University Medical Center, Maywood, IL 60153, USA;
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Abstract Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes. However, blood pressure (BP) responses to potassium supplementation vary among individuals. This study was designed to examine the association between 12 single nucleotide polymorphisms (SNPs) in the adducin 1 alpha (ADD1) and guanine nucleotide binding protein (G protein) beta polypeptide 3 (GNB3) genes and systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) responses to potassium-supplementation. We conducted a 7-day high-sodium intervention (307.8 mmol sodium/day) followed by a 7-day high-sodium with potassium-supplementation (60 mmol potassium/day) among 1906 Han Chinese participants from rural north China. BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer. We identified significant associations between ADD1 variant rs17833172 and SBP, DBP, and MAP responses to potassium-supplementation (all P<0.0001) that remained significant after adjustment for multiple comparisons. In participants that were heterozygous or homozygous for the G allele of this marker, SBP, DBP, and MAP response to potassium-supplementation were −3.52 (−3.82, −3.21), −1.41 (−1.66, −1.15) and −2.12 (−2.37, −1.87), respectively, as compared to the corresponding responses of 1.99 (0.25, 3.73), −0.65 (−0.10, −0.21), and −0.23 (−0.37, 0.83), respectively, for those who were homozygous for A allele. In addition, participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation (P = 0.0041 and 0.01, respectively), which was also significant after correction for multiple testing. DBP and MAP responses to potassium-supplementation were −1.36 (−1.63, −1.10) and −2.07 (−2.32, −1.82) for those with at least G allele compared to corresponding responses of 0.86 (−0.68, 2.40) and −0.45 (−1.74, 0.84) for those who were homozygous for A allele. In summary, our study identified novel associations between genetic variants of the ADD1 gene and BP response to potassium-supplementation, which could have important clinical and public health implications. Future studies aimed at replicating these novel findings are warranted.
Keywords blood pressure      genetics      polymorphism      die-tary potassium      potassium sensitivity      adducin 1 alpha (ADD1)      guanine nucleotide binding protein beta polypeptide 3 (GNB3)      
Issue Date: 05 March 2010
 Cite this article:   
Dai-Hai YU PhD,Jian-Feng HUANG MD,Ji-Chun CHEN MS, et al. Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation[J]. Front. Med., 2010, 4(1): 59-66.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-010-0015-8
https://academic.hep.com.cn/fmd/EN/Y2010/V4/I1/59
Adrogue H J, Madias N E. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med, 2007, 356(19):1966―1978

doi: 10.1056/NEJMra064486
Iwamoto T, Kita S. Hypertension,Na+/Ca2+ exchanger,and Na+, K+-ATPase. Kidney Int, 2006, 69(12): 2148―2154

doi: 10.1038/sj.ki.5000421
O'Shaughnessy K M, Karet F E. Salt handling and hypertension. J ClinInvest, 2004, 113(8): 1075―1081
He F J, MacGregor G A. Fortnightly review: Beneficial effects of potassium. BMJ, 2001, 323(7311): 497―501

doi: 10.1136/bmj.323.7311.497
He J, Gu D, Chen J, Jaquish C E, Rao D C, Hixson J E, Chen J C, Duan X, Huang J F, Chen C S, Kelly T N, Bazzano L A, Whelton P K; GenSalt Collaborative ResearchGroup. Gender difference in blood pressure responses to dietary sodiumintervention in the GenSalt study. J Hypertens, 2009, 27(1): 48―54

doi: 10.1097/HJH.0b013e328316bb87
Whelton P K, He J, Cutler J A, Brancati F L, Appel L J, Follmann D, Klag M J. Effects oforal potassium on blood pressure. Meta-analysis of randomized controlledclinical trials. JAMA, 1997, 277(20): 1624―1632

doi: 10.1001/jama.277.20.1624
Gu D, He J, Wu X, Duan X, Whelton P K. Effect of potassium supplementation onblood pressure in Chinese: a randomized, placebo-controlled trial. J Hypertens, 2001, 19(7):1325―1331.

doi: 10.1097/00004872-200107000-00019
Marteau J B, Zaiou M, Siest G, Visvikis-Siest S. Geneticdeterminants of blood pressure regulation. J Hypertens, 2005, 23(12): 2127―2143

doi: 10.1097/01.hjh.0000186024.12364.2e
Beeks E, Kessels A G, Kroon A A, van der Klauw M M, de Leeuw P W. Genetic predisposition to salt-sensitivity: a systematic review. J Hypertens, 2004, 22(7): 1243―1249

doi: 10.1097/01.hjh.0000125443.28861.0d
Bianchi G, Ferrari P, Staessen J A. Adducin polymorphism: detectionand impact on hypertension and related disorders. Hypertension, 2005, 45(3): 331―340

doi: 10.1161/01.HYP.0000156497.39375.37
Manunta P, Citterio L, Lanzani C, Ferrandi M. Adducin polymorphisms and the treatment of hypertension. Pharmacogenomics, 2007, 8(5): 465―472

doi: 10.2217/14622416.8.5.465
Beeks E, Janssen R G, Kroon A A, Keulen E T, Geurts J M, de Leeuw P W, de Bruin T W. Association between the alpha-adducin Gly460Trp polymorphismand systolic blood pressure in familial combined hyperlipidemia. Am J Hypertens, 2001, 14(12): 1185―1190

doi: 10.1016/S0895-7061(01)02216-6
Bagos P G, Elefsinioti A L, Nikolopoulos G K, Hamodrakas S J. The GNB3 C825T polymorphism and essential hypertension:a meta-analysis of 34 studies including 14,094 cases and 17,760 controls. J Hypertens, 2007, 25(3): 487―500

doi: 10.1097/HJH.0b013e328011db24
GenSalt: rationale, design,methods and baseline characteristics of study participants. J Hum Hypertens, 2007, 21(8): 639―646

doi: 10.1038/sj.jhh.1002207
Perloff D, Grim C, Flack J, Frohlich E D, Hill M, McDonald M, Morgenstern B Z. Human blood pressure determination by sphygmomanometry. Circulation, 1993, 88(5 Pt 1): 2460―2470
International HapMapConsortium. The International HapMap Project. Nature, 2003, 426(6968): 789―796

doi: 10.1038/nature02168
Hinds D, Risch M. The ASPEX package:affected sib-pair exclusion mapping v1.88, 1999
Abecasis G R, Cherny S S, Cookson W O, Cardon L R. GRR: graphical representation of relationship errors. Bioinformatics, 2001, 17(8): 742―743

doi: 10.1093/bioinformatics/17.8.742
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M A, Bender D, Maller J, Sklar P, de Bakker P I, Daly M J, Sham P C. PLINK: atool set for whole-genome association and population-based linkageanalyses. Am J Hum Genet, 2007, 81(3): 559―575

doi: 10.1086/519795
O'Connell J R, Weeks D E. PedCheck:a program for identification of genotype incompatibilities in linkageanalysis. Am J Hum Genet, 1998, 63(1): 259―266

doi: 10.1086/301904
Abecasis G R, Cherny S S, Cookson W O, Cardon L R. Merlin--rapid analysis of dense genetic maps using sparsegene flow trees. [see comment]. Nat Genet, 2002, 30(1): 97―101

doi: 10.1038/ng786
Benjamini Y, Hochberg Y. Controllingthe false discovery rate: A practical and powerful approach to multipletesting. J R Stat Soc, Series B (Methodological), 1995, 57(1): 289―300
Gerhard T, Gong Y, Beitelshees A L, Mao X, Lobmeyer M T, Cooper-DeHoff R M, Langaee T Y, Schork N J, Shriver M D, Pepine C J, Johnson J A; INVEST Investigators. Alpha-adducin polymorphism associated withincreased risk of adverse cardiovascular outcomes: results from GENEticSubstudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES). Am Heart J, 2008, 156(2): 397―404

doi: 10.1016/j.ahj.2008.03.007
Manunta P, Cusi D, Barlassina C, Righetti M, Lanzani C, D'Amico M, Buzzi L, Citterio L, Stella P, Rivera R, Bianchi G. Alpha-adducinpolymorphisms and renal sodium handling in essential hypertensivepatients. Kidney Int, 1998, 53(6): 1471―1478

doi: 10.1046/j.1523-1755.1998.00931.x
Schorr U, Blaschke K, Beige J, Distler A, Sharma A M. G-protein beta3 subunit 825T allele and response to dietary saltin normotensive men. J Hypertens, 2000, 18(7): 855―859

doi: 10.1097/00004872-200018070-00006
Daimon M, Sato H, Sasaki S, Toriyama S, Emi M, Muramatsu M, Hunt S C, Hopkins P N, Karasawa S, Wada K, Jimbu Y, Kameda W, Susa S, Oizumi T, Fukao A, Kubota I, Kawata S, Kato T. Salt consumption-dependentassociation of the GNB3 gene polymorphism with type 2 DM. Biochem Biophys Res Commun, 2008, 374(3): 576―580

doi: 10.1016/j.bbrc.2008.07.065
Schelleman H, Klungel O H, Witteman J C, Breteler M M, Hofman A, van Duijn C M, de Boer A, Stricker B H. Diuretic-gene interaction and the risk of myocardial infarction andstroke. Pharmacogenomics J, 2007, 7(5): 346―352

doi: 10.1038/sj.tpj.6500428
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