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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2010, Vol. 4 Issue (1) : 101-105     DOI: 10.1007/s11684-010-0017-6
Research articles |
Genetic association between the polymorphism of cytosolic PLA2 gene family and schizophrenia
Qiong YU PhD,Xiang-Fei MENG PhD,Jie-Ping SHI,Ya-Qin YU PhD,
Department of Epidemiology and Biostatistics, Center of Medical Genomics, School of Public Health, Jilin University, Changchun 130021, China;
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Abstract  Abnormal phospholipid metabolism in the brain plays an important role in neuropsychiatric diseases. Phospholipase A2 (PLA2) is a crucial element for normal neuro-physiological function. This study aims to investigate the genetic association between the polymorphism of cytosolic phospholipase A2 (cPLA2) family genes and schizophrenia among Han Chinese in the northern part of China. The polymerase chain reaction-based ligase detection reaction (PCR-LDR) was applied to detect the genotype ten single nucleotide polymorphisms (SNPs) of cPLA2 family genes among 201 pedigrees consisting of fathers, mothers and affected offsprings with schizophrenia. The pedigrees were collected from 2000 to 2006. Haplotype relative risk (HRR) test, transmission disequilibrium test (TDT), haplotype transmission analysis and multiple locus analysis were conducted to analyze the genotyping data. The genotypic frequency of cPLA2 gene did not deviate from Hardy-Weinberg equilibrium either in case or control group. HRR and TDT showed that the ten SNPs were not associated with schizophrenia (P>0.05). Analysis for haplotype transmission showed that no haplotype system was associated with schizophrenia (P>0.05). The conditioning on allele (COA) and conditioning on gene (COG) tests showed disease associations with the haplotype of rs2162886-rs1668589, rs891014-rs1668589 and rs2307279-rs7542180 (χ2=6.913, P=0.032; χ2=8.393, P=0.015; χ2€=8.447, P=0.038). Our data suggest that many loci in the cPLA2 family genes may be associated with schizophrenia.
Keywords schizophrenia      cytosolic phospholipase A2      ligase detection reaction      polymorphism      
Issue Date: 05 March 2010
URL:     OR
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