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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2010, Vol. 4 Issue (2) : 166-176     DOI: 10.1007/s11684-010-0036-3
Research articles |
Research advances of Legionella and Legionnaires’ disease
Xiao-Yong ZHAN MD,Chao-Hui HU PhD,Qing-Yi ZHU MD,
Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou 510330, China;
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Abstract  Legionella is a causative agent of legionellosis or Legionnaires’ disease. Infection with Legionella spp. is an important cause of community and hospital-acquired pneumonia. Moreover, infection with Legionella is one of the most common causes of severe pneumonia in community settings, and Legionella is isolated in 40% of hospital-acquired pneumonia cases. The clinical features of legionellosis or Legionnaires’ disease are not unique, which makes the diagnosis challenging. Macrolides and fluoroquinolones are the most widely used drugs in treatment. Early recognition, treatment and effective measures for prevention and control of the disease are important and required. Although there have been a lot of methods for diagnosis of Legionella infection, they were often time-consuming or complex, not suitable for clinical purposes. This review summarizes available information regarding the microbiology, taxonomy, epidemiology, pathogenesis and diagnosis of Legionnaires’ disease, with an emphasis on the laboratory diagnosis of infection with Legionella spp.
Keywords Legionella      Legionella pneumophila      diagnosis      Legionnaires&#8217      disease      
Issue Date: 05 June 2010
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-010-0036-3     OR     http://academic.hep.com.cn/fmd/EN/Y2010/V4/I2/166
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