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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med Chin    2010, Vol. 4 Issue (3) : 259-263     DOI: 10.1007/s11684-010-0095-5
HPV prevalence and genotyping in the cervix of Chinese women
Shao-Ming WANG, Jing LI, You-Lin QIAO()
Department of Cancer Epidemiology, Cancer Institute of Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
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The role of human papillomavirus (HPV) as an etiologic factor of cervical cancer has been firmly established, and prophylactic vaccines are now available and have been approved in many countries. Vaccination implies a promising future for cervical cancer prevention especially for countries with very limited access to screening. However, the vaccines are not accessible in mainland China at the moment, and much needs to be understood about the potential benefit when HPV vaccines are applied to Chinese women, and to make the vaccines more specific to Chinese women. This article reviews advanced multi-center, hospital/population-based studies of most recent years, and aims to draw a definitive conclusion on HPV prevalence and genotyping in cervical cancer and precancerous lesions in China from the aspect of study population, geographic areas and time period.

Keywords human papillomavirus (HPV) genotyping      cervical cancer      precancerous lesions      Chinese women     
Corresponding Authors: QIAO You-Lin,   
Issue Date: 05 September 2010
URL:     OR
subjectmulti-center studies
authorZhao et al. [6]Dai et al. Wu et al. Li et al. [3-5]Lo et al. [12]Bao et al. [7]Chen et al. [13]
age group (yr)17-5915-59-->18
study year1999-20082004-20051997-1999<20062004-2006
study centerBeijing, Shanghai, Guangzhou, Jiangsu, Shanxi, Jiangxi, Gansu, Henan, XinjiangShanxiShanghai-Zhejiang, Xinjiang, Sichuan, Beijing, Jiangxi, Hunan, Gansu, Chongqing, Nanjing, Guangxi, Shenzhen, Kunming, Zhengzhou, Liaoning, Dalian, Guangzhou, Xi’an
Hong Kong
study typesummary of 10 cross-sectional studiessummary of three cross-sectional studiesprospective and retrospective multi-center studymeta-analysishospital-based multi-center cross-sectional study
lab assaysHC2 (Qiagen)GP5+/6+ mediated PCRPCR (MY09/11, GP5+/6+)PCR (MY09/11, GP5+/6+, TS–only et al.)SPF10 LiPA25
high risk HPV prevalence
general populationwomen with cervical lesionsgeneral populationwomen with cervical lesions
HPV type distribution
1-16 (3.7%)a16 (20.3%)a16 (79.6%)16 (61.9%)b16 (76.7%)c
2-58 (2.1%)a58 (12.1%)a18 (7.5%)18 (7.7%)b18 (7.8%)c
3-52 (1.9%)a52 (8.8%)a58 (3.8%)58 (6.4%)b31 (3.2%)c
4-18 (1.1%)a18 (7.1%)a52 (2.6%)52 (3.5%)b52 (2.2%)c
5-39 (1.1%)a56 (4.9%)a31 (3.4%)b58 (2.2%)c
HPV: human papillomavirus; ICC: invasive cervical cancer; SCC: squamous cervical cancer; ADC: adenocarcinoma; CIN: cervical intraepithelial neoplasia; HSIL: high-grade squamous intraepithelial lesion; LSIL: low-grade squamous intraepithelial lesion. a: summary for the multicenter studies; b: HPV type distribution in ICC; c: HPV type distribution in SCC
Tab.1  Summary of multi-center studies on HPV genotyping among Chinese women
regionsSCC (%)CIN3 (%)CIN2 (%)predominant HPV types in SCC
Northeast96.498.490.916, 18, 59, 31, 52
North98.896.7100.016, 18, 31, 58
Northwest98.298.4100.016, 18, 59
Central100100.0100.016, 31, 58, 18, 52, 59
Southwest96.2100.0100.016, 18, 52, 58, 59
South96.7100.0100.016, 18, 52, 58, 59
East97.098.5100.016, 18, 31, 59, 52, 58
total97.698.899.316, 18, 31, 52, 58, 59
Tab.2  Geographic distribution of type specific HPV DNA typing results for ICC, CIN3 and CIN2
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