Please wait a minute...
Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med Chin    2010, Vol. 4 Issue (3) : 342-345     DOI: 10.1007/s11684-010-0099-1
RESEARCH ARTICLE |
The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis of infantile persistent jaundice
Sheng-Xuan LIU, Zhi-Hua HUANG()
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Download: PDF(127 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract  

The aim of this study was to investigate the value of technetium etifenin injection (99mTc-EHIDA) hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis between infantile hepatitis syndrome and biliary atresia. 99mTc-EHIDA hepatobiliary scintigraphy in combination with duodenal fluid examination was used for evaluation in 84 infants with persistent infantile jaundice. For diagnosing biliary atresia, the sensitivity and specificity of scintigraphy were 100% and 74.5%, respectively; the sensitivity and specificity of scintigraphy in combination with duodenal fluid examination were 100% and 100%, respectively. In conclusion, hepatobiliary scintigraphy, which is a noninvasive, safe, valuable examination method, in combination with examination of duodenal fluid, is of value for the differential diagnosis between infantile hepatitis syndrome and biliary atresia.

Keywords jaundice      radionuclide hepatobiliary scintigraphy      duodenal drainage     
Corresponding Authors: HUANG Zhi-Hua,Email:zhhuang@tjh.tjmu.edu.cn   
Issue Date: 05 September 2010
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-010-0099-1     OR     http://academic.hep.com.cn/fmd/EN/Y2010/V4/I3/342
Fig.1  Images of extrahepatic biliary atresia. It shows radiological imaging in liver, heart and kidney but no radiological imaging in gallbladder or intestine.
Fig.2  Images of infantile hepatitis syndrome. It shows radiological imaging in liver, heart, kidney, gallbladder and intestine.
1 Huang Z H, Dong Y C. Dynamic duodenal fluid examination differential diagnose infantile continuous obstructive jaundice. Zhonghua Er Ke Za Zhi , 2004, 42(1): 54–56 (in Chinese)
2 Lee C H, Wang P W, Lee T T, Tiao M M, Huang F C, Chuang J H, Shieh C S, Cheng Y F. The significance of functioning gallbladder visualization on hepatobiliary scintigraphy in infants with persistent jaundice. J Nucl Med , 2000, 41(7): 1209–1213
3 Gerhold J P, Klingensmith W C 3rd, Kuni C C, Lilly J R, Silverman A, Fritzberg A R, Nixt T L. Diagnosis of biliary atresia with radionuclide hepatobiliary imaging. Radiology , 1983, 146(2): 499–504
4 Nadel H R. Hepatobiliary scintigraphy in children. Semin Nucl Med , 1996, 26(1): 25–42
doi: 10.1016/S0001-2998(96)80014-6
5 Charearnrad P, Chongsrisawat V, Tepmongkol S, Poovorawan Y. The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. J Med Assoc Thai , 2003, 86(Suppl 2): S189–S194
6 Esmaili J, Izadyar S, Karegar I, Gholamrezanezhad A. Biliary atresia in infants with prolonged cholestatic jaundice: diagnostic accuracy of hepatobiliary scintigraphy. Abdom Imaging , 2007, 32(2): 243–247
doi: 10.1007/s00261-006-9049-4
7 Poddar U, Bhattacharya A, Thapa B R, Mittal B R, Singh K. Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med , 2004, 45(9): 1488–1492
8 Fischler B, Woxenius S, Nemeth A, Papadogiannakis N. Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection. J Pediatr Surg , 2005, 40(3): 541–546
doi: 10.1016/j.jpedsurg.2004.11.035
9 Fjaer R B, Bruu A L, Nordb? S A. Extrahepatic bile duct atresia and viral involvement. Pediatr Transplant , 2005, 9(1): 68–73
doi: 10.1111/j.1399-3046.2005.00257.x
10 Stipsanelli K, Koutsikos J, Papantoniou V, Arka A, Palestidis C, Tsiouris S, Manolaki A, Zerva C. Hepatobiliary scintigraphy and gamma-GT levels in the differential diagnosis of extrahepatic biliary atresia. Q J Nucl Med Mol Imaging , 2007, 51(1): 74–81
11 Greene H L, Helinek G L, Moran R, O’Neill J. A diagnostic approach to prolonged obstructive jaundice by 24-hour collection of duodenal fluid. J Pediatr , 1979, 95(3): 412–414
doi: 10.1016/S0022-3476(79)80519-3
12 Faweya A G, Akinyinka O O, Sodeinde O. Duodenal intubation and aspiration test: utility in the differential diagnosis of infantile cholestasis. J Pediatr Gastroenterol Nutr , 1991, 13(3): 290–292
doi: 10.1097/00005176-199110000-00009
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed