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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2010, Vol. 4 Issue (4) : 371-377     DOI: 10.1007/s11684-010-0130-6
Research articles |
Hilar cholangiocarcinoma: Pathology and tumor biology
Dong KUANG,Guo-Ping WANG,
Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
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Abstract  Hilar cholangiocarcinoma, first described by Klatskin in 1965, is a relatively rare tumor arising from the bile ducts. The histomorphological features of hilar cholangiocarcinoma are identical with other extra- and intra-hepatic bile duct carcinomas. The most common disease associated with cholangiocarcinoma is primary sclerosing cholangitis. The development of cholangiocarcinoma is a multistep process associated with several mutations in oncogenes and tumor-suppressor genes. Based on macroscopic appearance, three distinct subtypes have been described: sclerosing, nodular, and papillary. Microscopically, more than 95% of tumors are adenocarcinomas. Hilar cholangiocarcinoma is a slowly growing tumor and tends to spread longitudinally along the bile ducts with neural, perineural, and subepithelial extension. Lymph node invasion can be found in 30%–50% patients at the time of diagnosis, but blood-born metastases are rare and usually occur at late stages.
Keywords hilar cholangiocarcinoma      morphology      primary sclerosing cholangitis      metastasis      growth      
Issue Date: 05 December 2010
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-010-0130-6     OR     http://academic.hep.com.cn/fmd/EN/Y2010/V4/I4/371
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