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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2011, Vol. 5 Issue (1) : 40-44     DOI: 10.1007/s11684-011-0108-z
Stem cell niches and endogenous electric fields in tissue repair
Li LI, Jianxin JIANG()
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
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Adult stem cells are responsible for homeostasis and repair of many tissues. Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, which is recognized to have an important role in regulating tissue maintenance and repair. In wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, and participate in the repair process. Many regulatory factors are involved in the stem cell-based repair process, including stem cell niches and endogenous wound electric fields, which are present at wound tissues and proved to be important in guiding wound healing. Here we briefly review the role of stem cell niches and endogenous electric fields in tissue repair, and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords stem cell      stem cell niche      electric field      tissue repair     
Corresponding Authors: JIANG Jianxin,   
Issue Date: 05 March 2011
URL:     OR
Fig.1  Model for a stem cell niche in a skin wound. A stem cell niche is involved of stem cell itself; stromal support cells; extracellular matrix proteins; blood vessels and neural inputs. In a wound site, electric fields arise, last for hours and days until the wound heals. So there is a spatial and time relationship between electric fields and stem cells at the wound site. Based on these, we hypothesize that endogenous wound electric fields exert effects on local stem cells and is one part of local stem cell niche.
Fig.2  Perpendicular reorientation of human mesenchymal stem cells under electric stimulation. Before electric stimulation, human umbilical cord mesenchymal stem cells were radomly oriented. After 200mV/mm electrical stimulation for 5 hours, these cells re-oriented perpendicularly to the EF direction. Bar=100 μm
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