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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2011, Vol. 5 Issue (1) : 8-14     DOI: 10.1007/s11684-011-0109-y
The influence of brain death on donor liver and the potential mechanisms of protective intervention
Shui-Jun ZHANG(), Tao WANG
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
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Brain-dead donors have become one of the main sources of organs for transplantation in Western countries. The quality of donor organs is closely related to the outcome of the transplantation. Experimental studies have confirmed the inferior graft survival of livers from brain-dead donors compared with those from living donors. Studies conducted in the past 10 years have shown that brain death is associated with effects on the decreased donor organ quality. However, whether the decrease in the viability of donor organs is caused by brain death or by the events before and after brain death remains uncertain. The purpose of this review is to introduce the advances and controversies regarding the influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective interventions for donor livers.

Keywords brain death      donor liver     
Corresponding Authors: ZHANG Shui-Jun,   
Issue Date: 05 March 2011
URL:     OR
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