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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2011, Vol. 5 Issue (2) : 123-126     DOI: 10.1007/s11684-011-0124-z
Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China
Jian Wang(), Wen Zou
Traditional Chinese Medicine Center for AIDS Prevention and Treatment, China Academy of Chinese Medicine Sciences, Beijing 100700, China
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Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency syndrome (AIDS) in China in recent years. In this article, we summarize the recent major developments in human immunodeficiency virus/AIDS (HIV/AIDS) treatment with TCM. The use of TCM is associated with preventing or alleviating HIV-related symptoms, reducing treatment side effects, and improving the quality of life. The potential beneficial effects of TCM should be confirmed through extensive and rigorous trials.

Keywords HIV/AIDS      traditional Chinese medicine     
Corresponding Authors: Wang Jian,   
Issue Date: 05 June 2011
URL:     OR
1 Au TK, Lam TL, Ng TB, Fong WP, Wan DC. A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. Life Sci 2001; 68(14): 1687-1694
doi: 10.1016/S0024-3205(01)00945-6 pmid:11263681
2 Kobayashi Y, Watanabe M, Ogihara J, KATO J, OISHI K. Inhibition of HIV-1 reverse transcriptase by methanol extracts of commercial herbs and spices. J Jap Society Food Sci Technol 2000; 47(8): 642-645
3 Lam TL, Lam ML, Au TK, Ip DT, Ng TB, Fong WP, Wan DC. A comparison of human immunodeficiency virus type-I protease inhibition activities by the aqueous and methanol extracts of Chinese medicine herbs. Life Sci 2000; 67(23): 2888-2889
doi: 10.1016/S0024-3205(00)00864-X
4 Gai L, Song CQ, Hu ZB. Review of anti-HIV plants. Foreign Medical Sciences 2001; 23(9): 139-142 (in Chinese)
5 He JH, Mai ED. Review of AIDS treatment with Chinese medicine. Chinese Pharmaceutical and Clinical Research 2004; 4(2): 454-456 (in Chinese)
6 Chen X, Yang L, Zhang N, Turpin JA, Buckheit RW, Osterling C, Oppenheim JJ, Howard OM. Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. Antimicrob Agents Chemother 2003; 47(9): 2810-2816
doi: 10.1128/AAC.47.9.2810-2816.2003 pmid:12936978
7 Dan S, Peng ZL. Randomized double blind placebo paralleled clinical research on HIV/AIDS with Qiankunning Tablets. Journal of Traditional Chinese Medicine Research 2003; 21(9): 1472-1474
8 Zhao HX, Zhang FJ, Gao GJ, Yu L, Lu LH, Wen Y, Han N, Zhao Y, Li J. A 24 week chinical observation on the officaoy and safety of a domestic generic ARV drug combined with the Chinese treating medicine in the treatment of HIV/AIDS patients. Chinese Journal of AIDS & STD 2006; 12(4): 297-299
9 Sangkitporn S, Shide L, Klinbuayaem V, Leenasirimakul P, Wirayutwatthana NA, Leechanachai P, Dettrairat S, Kunachiwa W, Thamlikitkul V. Efficacy and safety of zidovudine and zalcitabine combined with a combination of herbs in the treatment of HIV-infected Thai patients. Southeast Asian J Trop Med Public Health 2005; 36(3): 704-708
10 Wang J, Liu Y, Zou W, He LY, Yan SY, Yuan YH. Clinical observations on 100 HIV/ AIDS cases treated with Chinese herb Aining granule plus HAART. Chinese Journal of AIDS & STD 2008; 14(2): 101-104
11 Wang J, Yang FZ, Zhao M, Zhang YH, Zhang YX, Liu Y, Liu WM, Wang FS, Xu SL, Yu ZM, Xie YM, Zhou XZ, Jiang TJ. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4. Chin J Integr Med 2006; 12(1): 6-11
doi: 10.1007/BF02857422 pmid:16571276
12 Liu Y, Zou W, Wang J. General Introduction of clinical researches on HIV/AIDS treatment with TCM. China Journal of Traditional Chinese Medicine and Pharmacy 2009; 24(3): 350-353
13 Wang J, Liu Y, Zou W. Overview of AIDS treatment with Traditional Chinese Medicine. Chinese Journal of AIDS & STD 2010; 16(3): 313-317
14 Fang SS, Wang J, Huang WA. Effect of medicine of Aining Granule on human liver cytochrome P4501A2,2D6 and 3A4by using pooled human liver microsomes and relatable cryopreserved human primary hepatocytes. Drug Metab Rev 2006; 53(38): 57-58
15 Li XH, Wang FM, Gao YQWang YZ. Clinical observation of AIZHI 1 prescription used to treat HIV/AIDS patients with abnormal fatty distribution resulting from HAART. Chinese Journal of AIDS & STD 2010; 16(3): 226-228
16 Wang FM. Clinical study on HIV related peripheral neuropathy with TCM. Traditional Chinese Medcine of Neimenggu 2008; (1):15-16
17 Hao ZQ. Observation on HIV related peripheral neuritis. Traditional Chinese Medcine of Liaoning 2008; 35(5): 721-722
18 Fang L, Duan CY, Wang L. Study on positive role of traditional Chinese drugs in improving immue functions among HAART receivers with incomplete immunity restoration. Chinese Journal of AIDS & STD 2010; 16(3): 229-230
19 Jiang SQ, Sun HX, Xu YM, Pei JW, Wang HL. The impact of Jing Yuankang capsule on the level of peripheral leukocytes of 116 cases of AIDS. China Journal of Traditional Chinese Medicine and Pharmacy 2009; 24(3): 327-330
20 Yang X, Jiang F, Zhou C. To treat 49 cases of gastrointestinal adverse action due to HAART therapy. Traditional Medicinal Research 2008; 21(12): 23-26 (in Chinese)
21 Wang JD, He GE, Zeng JQ. Moxibustion with Moxa sticks Treat 50 cases Diarrhea HIV/AIDS Patients. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque 2006; 21(122): 14-16
22 Wang JR, Chen XR, Zhang Q, Liu XN, Xu QN, Lu HZ. Effect of moxibustion on immunological function in the patient of AIDS of spleen-kidney yang-deficiency. Zhongguo Zhen Jiu 2007; 27(12): 892-894 (in Chinese)
23 Guo Y, Qian BY. Clinial Observation on 65 cases of HIV/AIDS patients with diarrhea. Guangming Journal of Chinese Medicine 2008; 23(1): 27-28
24 He LY, Liu BY, Wang J. Establishment of an index system to evaluate the efficacy of traditional Chinese medicines in treating HIV/AIDS. Chinese Journal of AIDS & STD 2010; 16(3): 288-291
25 Wang J, Liu Y, Zou W. Clinical observation of effect of traditional Chinese herbs on CD4 count in 807 people living with HIV/AIDS. Chinese Journal of AIDS & STD 2010; 16(3): 208-210
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