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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2011, Vol. 5 Issue (2) : 229-234     DOI: 10.1007/s11684-011-0139-5
RESEARCH ARTICLE |
Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice
Liyun He1(), Tiancai Wen1, Shiyan Yan1, Runjin Li2, Zufa Liu3, Hui Ren4, Jinmin Liu5, Fengshan Zhang6, Jianzhong Wu7, Jian Liu8
1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China; 2. Inner Mongolia People’s Hospital, Hohhot 010017, China; 3. Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China; 4. The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China; 5. Beijing University of Traditional Chinese Medicine Oriental Hospital, Beijing 100078, China; 6. Tongliao Hospital, Tongliao 026000, China; 7. China Association Against Epilepsy, Beijing 100044, China; 8. Kunming Chinese Medicine Factory Co., Ltd., Kunming 650228, China
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Abstract  

We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 137 patients, we combined Dianxianning with chemical medicine, which is the basic treatment. For the control group with 69 patients, we added placebo. The results showed that 1) Effect on seizure rate: After a three-month treatment, the seizure rate of the treatment group decreased by 37.84% on average, whereas that of the control group decreased by 13.18% on average. Statistically comparing the two groups, there was a significant difference between these groups (P<0.05). 2) Effect on seizure frequency: As time passed, the frequency in each group gradually decreased. After a three-month treatment, there was a significant difference between the two groups (P<0.05). 3) Comparison between the before and after treatment of each group: There was a very significant difference between the two groups (P<0.0001). The results indicated that, as an additive treatment, Dianxianning has a good effect on controlling the epilepsy seizure rate and frequency management. It is more effective than using chemical medicine alone.

Keywords Dianxianning      epilepsy seizure      evaluation     
Corresponding Authors: He Liyun,Email:hely3699@163.com   
Issue Date: 05 June 2011
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-011-0139-5     OR     http://academic.hep.com.cn/fmd/EN/Y2011/V5/I2/229
ITT analysis
Experimental group n = 137Control group n = 69StatisticP
Epilepsy seizure rate2.19±8.650.09±12.27-1.2080.227
Epilepsy frequency37.84±65.24Δ13.18±96.21-2.01100.0443
PP analysis
Experimental group n = 129Control group n = 67statisticP
Epilepsy seizure rate2.84±6.60-0.01±12.44-1.6680.095
Epilepsy frequency42.2±54.79Δ11.23±96.9-2.40610.0161
Tab.1  Comparison of the epilepsy seizure rate and frequency between two groups in three months before and after treatment
TimeITT analysis
Experimental group(n = 137)Control group(n = 69)StatisticP
Baseline2.89±3.813.26±7.27-0.03360.9732
1 month after treatment1.31±2.841.99±6.180.75320.4513
2 months after treatment1.30±2.732.09±7.36-0.12980.8968
3 months after treatment0.99±2.73Δ1.55±4.921.99460.0461
TimePP analysis
Experimental group(n = 137)Control group(n = 69)StatisticP
Baseline2.80±3.613.30±7.380.06510.9481
1 month after treatment1.09±1.672.03±6.261.02000.3077
2 months after treatment1.08±1.452.13±7.460.10840.9137
3 months after treatment0.75±1.40Δ1.58±4.992.33080.0198
Tab.2  Comparison of the epilepsy seizure rate and the difference between two groups at different times
One month after-baselineStatisticPTwo months after-baselinestatisticPThree months after-baselineStatisticP
Experimental group-1.58±2.93ΔΔ-6.29&lt;0.0001-1.59±3.14-5.93&lt;0.0001-1.90±3.36-6.61&lt;0.0001
Control group-1.28±2.38ΔΔ-4.46&lt;0.0001-1.17±2.41-4.05&lt;0.0001-1.71±3.30-4.3&lt;0.0001
Tab.3  Comparison of the epilepsy seizure rate in two groups at different times(ITT analysis, )
One month after-baselineStatisticPTwo months after-baselineStatisticPThree months after-baselineStatisticP
Experimental group-1.71±2.87ΔΔ-6.75&lt;0.0001-1.72±3.10-6.31&lt;0.0001-2.05±3.32-7&lt;0.0001
Control group-1.27±2.41ΔΔ-4.31&lt;0.0001-1.16±2.44-3.9&lt;0.0001-1.72±3.35-4.19&lt;0.0001
Tab.4  Comparison of the epilepsy seizure rate in each group before and after treatment(PP analysis, )
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