Translational research on novel drug-eluting stents in percutaneous coronary intervention

doi:10.1007/s11684-011-0167-1

Front Med

2011, Vol. 5

Issue (4) : 395-400 https://doi.org/10.1007/s11684-011-0167-1

REVIEW

Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han(

), Kai Xu, Chenghui Yan

Department of Cardiology, General Hospital of Shenyang Military Region, PLA, Shenyang 110840, China

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Abstract

Although first-generation drug-eluting stents (DES) have markedly reduced restenosis, complications of late and very late in-stent thrombosis have emerged as prime limitations to this technology. The development of new DES is a key process to prevent these complications. Translational research plays a very important role in experiments which determine the safety and efficacy of DES before human clinical trials. The present review focuses on translational research of novel DES, including drug discovery, creation of preclinical research models, planning and conducting of first-in-man studies, and developing next-generation DES systems.

Keywords translational research drug-eluting stents percutaneous coronary intervention

Corresponding Author(s): Han Yaling,Email:hanyaling@263.net

Issue Date: 05 December 2011

Cite this article:

Yaling Han,Kai Xu,Chenghui Yan. Translational research on novel drug-eluting stents in percutaneous coronary intervention[J]. Front Med, 2011, 5(4): 395-400.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-011-0167-1
https://academic.hep.com.cn/fmd/EN/Y2011/V5/I4/395

Tab.1 Overview of potential drugs used in DES translational research

Tab.2 Advantages and disadvantages of rabbit iliac arteries model versus porcine coronary arteries model

Fig.1 Adenovirus-mediated cellular repressor of E1A genes transferred to the balloon-injured artery and inhibited intimal hyperplasia (a and a＇). In these representative micrographs of arterial sections stained with hematoxylin and eosin, the arrowheads define the neointima. The areas of the neointima and the media in the cross-sections of the artery were measured morphometrically and then plotted. The neointima area and the intima/media ratio of adenovirus-CREG-transduced arteries were much smaller than those of the no treatment saline (NT) and adenovirus green fluorescent protein (Ad-GFP) controls 28 days after balloon injury (<0.01); = 5 for each group (b and b＇). Angiography of common carotid arteries was performed in the Ad-CREG, Ad-GFP, and saline-treated groups. The arrows define the minimal lumen diameter. The diameter stenosis rate of Ad-CREG-transduced arteries was significantly reduced compared with those of NT and Ad-GFP groups 28 days after vascular injury (<0.01); = 5 for each group (b＇). Data are presented with the standard deviation.

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