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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases |
Chong Liu, Dingfeng Su() |
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China |
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Abstract Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
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Keywords
α7 nicotinic acetylcholine receptor
cardiovascular diseases
baroreflex sensitivity
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Corresponding Author(s):
Su Dingfeng,Email:dfsu2008@gmail.com
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Issue Date: 05 March 2012
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