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Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection |
Yu Liao, Yufei Xiang, Zhiguang Zhou() |
Diabetes Center, 2nd Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha 410011, China |
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Abstract Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and age of diagnosis. Besides, β cell function, metabolic parameters, genetic factors and cell immunity may also contribute to the formulation of the criteria. Here, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.
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Keywords
LADA
diagnostic criteria
autoantibodies
insulin independence
age of diagnosis
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Corresponding Author(s):
Zhou Zhiguang,Email:zhouzg@hotmail.com
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Issue Date: 05 September 2012
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1 |
Leslie RD, Williams R, Pozzilli P. Clinical review: type 1 diabetes and latent autoimmune diabetes in adults: one end of the rainbow. J Clin Endocrinol Metab 2006; 91(5): 1654-1659 doi: 10.1210/jc.2005-1623 pmid:16478821
|
2 |
Rolandsson O, Palmer JP. Latent autoimmune diabetes in adults (LADA) is dead: long live autoimmune diabetes! Diabetologia 2010; 53(7): 1250-1253 doi: 10.1007/s00125-010-1713-0 pmid:20336277
|
3 |
Teng J, Leslie RD. Type 1 diabetes and latent autoimmune diabetes in adults. J Cent S Univ (Med Sci) (Zhong Nan Da Xue Xue Bao Yi Xue Ban) 2006; 31(6): 809-813 (in Chinese) pmid:17213574
|
4 |
Fourlanos S, Dotta F, Greenbaum CJ, Palmer JP, Rolandsson O, Colman PG, Harrison LC. Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia 2005; 48(11): 2206-2212 doi: 10.1007/s00125-005-1960-7 pmid:16193284
|
5 |
Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Zhou Z, Shan G, He J ; China National Diabetes and Metabolic Disorders Study Group. Prevalence of diabetes among men and women in China. N Engl J Med 2010; 362(12): 1090-1101 doi: 10.1056/NEJMoa0908292 pmid:20335585
|
6 |
Leslie RD, Kolb H, Schloot NC, Buzzetti R, Mauricio D, De Leiva A, Yderstraede K, Sarti C, Thivolet C, Hadden D, Hunter S, Schernthaner G, Scherbaum W, Williams R, Pozzilli P. Diabetes classification: grey zones, sound and smoke: Action LADA 1. Diabetes Metab Res Rev 2008; 24(7): 511-519 doi: 10.1002/dmrr.877 pmid:18615859
|
7 |
Naik RG, Brooks-Worrell BM, Palmer JP. Latent autoimmune diabetes in adults. J Clin Endocrinol Metab 2009; 94(12): 4635-4644 doi: 10.1210/jc.2009-1120 pmid:19837918
|
8 |
Groop L, Tuomi T, Rowley M, Zimmet P, Mackay IR. Latent autoimmune diabetes in adults (LADA)—more than a name. Diabetologia 2006; 49(9): 1996-1998 doi: 10.1007/s00125-006-0345-x pmid:16819610
|
9 |
Myhill P, Davis WA, Bruce DG, Mackay IR, Zimmet P, Davis TME. Chronic complications and mortality in community-based patients with latent autoimmune diabetes in adults: the Fremantle Diabetes Study. Diabet Med 2008; 25(10): 1245-1250 doi: 10.1111/j.1464-5491.2008.02562.x pmid:19046207
|
10 |
Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles W, Mackay IR. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 1993; 42(2): 359-362 doi: 10.2337/diabetes.42.2.359 pmid:8425674
|
11 |
Zimmet PZ, Tuomi T, Mackay IR, Rowley MJ, Knowles W, Cohen M, Lang DA. Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabet Med 1994; 11(3): 299-303 doi: 10.1111/j.1464-5491.1994.tb00275.x pmid:8033530
|
12 |
Scherbaum WA. Type 1, type 2 diabetes, MODY and LADA. Making a differential diagnosis. MMW Fortschr Med 2001; 143(37): 45-48 (in German) pmid:11599293
|
13 |
Silva ME. Do we need to diagnosis Latent Autoimmune Diabetes in Adults (LADA)? Arq Bras Endocrinol Metabol 2007; 51(1): 8-10 (in Portuguese) doi: 10.1590/S0004-27302007000100004 pmid:17435850
|
14 |
Pan X, Yang W, Xiao J, Chen S. Clinical characteristic and main diagnostic points of latent autoimmune diabetes in adults. Chin J Integr Med (Zhong Hua Nei Ke Za Zhi) 1997; 36(3): 159-164 (in Chinese)
|
15 |
Zhou Z. Where is the forward road of LADA study? Chin J Endocrinol Metab (Zhonghua Nei Fen Mi Dai Xie Za Zhi) 2005; 21(4): 301-303 (in Chinese)
|
16 |
Zhou Z, Wu H. Diagnosis and treatments of latent autoimmune diabetes in adults. Chin J Endocrinol Metab (Zhonghua Nei Fen Mi Dai Xie Za Zhi) 1998; 14(1): 1-2 (in Chinese)
|
17 |
Chi L, Liu X, Li X, Nie B, Li X. The diagnostic criteria of latent autoimmune diabetes of adults. J Chin Physicians (Zhongguo Yi Shi Za Zhi) 2006; 8(5): 610-613 (in Chinese)
|
18 |
Li X, Huang G, Yan X, Yang L, Zhou ZG. Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults. J South Med Univ (Nan Fang Yi Ke Da Xue Xue Bao) 2010; 30(6): 1247-1249 (in Chinese) pmid:20584648
|
19 |
Huang G, Wang X, Li Z, Li H, Li X, Zhou Z. Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese. Acta Diabetol 2010May16. [Epub ahead of print] doi: 10.1007/s00592-010-0196-2 doi: 10.1007/s00592-010-0196-2 pmid:20473693
|
20 |
Bottazzo GF, Bosi E, Cull CA, Bonifacio E, Locatelli M, Zimmet P, Mackay IR, Holman RR. IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71). Diabetologia 2005; 48(4): 703-708 doi: 10.1007/s00125-005-1691-9 pmid:15765222
|
21 |
Dang M, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, Gottlieb PA, Davidson HW. Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. J Immunol 2011; 186(10): 6056-6063 doi: 10.4049/jimmunol.1003815 pmid:21471440
|
22 |
Li X, Zhou ZG, Huang G, Yan X, Yang L, Chen XY, Wang JP. Optimal cutoff point of glutamate decarboxylase antibody titers in differentiating two subtypes of adult-onset latent autoimmune diabetes. Ann N Y Acad Sci 2004; 1037(1): 122-126 doi: 10.1196/annals.1337.019 pmid:15699504
|
23 |
van Deutekom AW, Heine RJ, Simsek S. The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus. Diabet Med 2008; 25(2):117-125 doi: 10.1111/j.1464-5491.2007.02316.x pmid:18028440
|
24 |
Weber P, Ambrosova P, Canov P, Weberova D, Kuklinek P, Meluzinova H, Matejovska-Kubesova H, Cejkova P, Bielakova K, Cerna M. GAD antibodies in T1D and LADA—relations to age, BMI, c-peptide, IA-2 and HLA-DRB1*03 and DRB1*04 alleles. Adv Gerontol 2011; 24(2): 312-318 pmid:21957594
|
25 |
Lampasona V, Petrone A, Tiberti C, Capizzi M, Spoletini M, di Pietro S, Songini M, Bonicchio S, Giorgino F, Bonifacio E, Bosi E, Buzzetti R. Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: non insulin requiring autoimmune diabetes (NIRAD) 4. Diabetes Care 2010; 33(1): 104-108 doi: 10.2337/dc08-2305 pmid:19808923
|
26 |
Yan X, Zhou Z, Huang G, Wang J, Yang L. Optimization of radioligand assays for islet autoantibodies. J Chin Physicians (Zhongguo Yi Shi Za Zhi) 2004; 6(6): 731-734 (in Chinese)
|
27 |
Brophy S, Yderstraede K, Mauricio D, Hunter S, Hawa M, Pozzilli P, Schernthaner G, Schloot N, Buzzetti R, Davies H, Leslie D, Williams R. Time to insulin initiation cannot be used in defining latent autoimmune diabetes in adults. Diabetes Care 2008; 31(3): 439-441 doi: 10.2337/dc07-1308 pmid:18083788
|
28 |
Zhou J, Ma XJ, Bao YQ, Pan XP, Lu W, Hu C, Xiang KS, Jia WP. Study on prevalence of latent autoimmune diabetes in adults and its relationship with metabolic syndrome. Natl Med J China (Zhonghua Yi Xue Za Zhi) 2009; 89(18): 1250-1254 (in Chinese) pmid:19595178
|
29 |
Horton V, Stratton I, Bottazzo GF, Shattock M, Mackay I, Zimmet P, Manley S, Holman R, Turner R. Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). Diabetologia 1999; 42(5): 608-616 doi: 10.1007/s001250051202 pmid:10333055
|
30 |
Weber P, Meluzínová H, Kubesová H, Ambrosová P, Polcarová V, Cejkova P, Cerna M. Type 1 diabetes and LADA- occurrence of HLA-DRB1*03 and DRB1*04 alleles in two age different groups of diabetics. Adv Gerontol 2009; 23(2): 243-248 pmid:21033293
|
31 |
Yang Z, Wang K, Li T, Sun W, Li Y, Chang YF, Dorman JS, LaPorte RE. Childhood diabetes in China. Enormous variation by place and ethnic group. Diabetes Care 1998; 21(4): 525-529 doi: 10.2337/diacare.21.4.525 pmid:9571336
|
32 |
Davies H, Brophy S, Fielding A, Bingley P, Chandler M, Hilldrup I, Brooks C, Williams R. Latent autoimmune diabetes in adults (LADA) in South Wales: incidence and characterization. Diabet Med 2008; 25(11): 1354-1357 pmid:19046228
|
33 |
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. Quality-of-life measures in children and adults with type 1 diabetes. Diabetes Care 2010; 33(10): 2175-2177 doi: 10.2337/dc10-0331 pmid:20696865
|
34 |
Yang L, Zhou ZG, Huang G, Yan X. Islet β cell function in latent autoimmune diabetes in adults with islet cell antibodies. J Cent S Univ (Med Sci) (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2004; 29(3): 309-314 (in Chinese) pmid:16136967
|
35 |
Yang L, Zhou ZG, Huang G, Ouyang LL, Li X, Yan X. Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes. World J Gastroenterol 2005; 11(19): 2900-2905 pmid:15902725
|
36 |
Li X, Zhou Z, Huang G, Su H, Yan X, Yang L. Metabolic syndrome in adult-onset latent autoimmune diabetes. Metab Syndr Relat Disord 2005; 3(2): 174-180 doi: 10.1089/met.2005.3.174 pmid:18370724
|
37 |
Hawa MI, Thivolet C, Mauricio D, Alemanno I, Cipponeri E, Collier D, Hunter S, Buzzetti R, de Leiva A, Pozzilli P, Leslie RD. Metabolic syndrome and autoimmune diabetes: action LADA 3. Diabetes Care 2009; 32(1): 160-164 doi: 10.2337/dc08-1419 pmid:18945926
|
38 |
Baum P, Hermann W, Verlohren HJ, Wagner A, Lohmann T, Grahmann F. Diabetic neuropathy in patients with “latent autoimmune diabetes of the adults” (LADA) compared with patients with type 1 and type 2 diabetes. J Neurol 2003; 250(6): 682-687 doi: 10.1007/s00415-003-1055-7 pmid:12796829
|
39 |
Arikan E, Sabuncu T, Ozer EM, Hatemi H. The clinical characteristics of latent autoimmune diabetes in adults and its relation with chronic complications in metabolically poor controlled Turkish patients with type 2 diabetes mellitus. J Diabetes Complications 2005; 19(5): 254-258 doi: 10.1016/j.jdiacomp.2005.02.004 pmid:16112499
|
40 |
Andersen MK, Lundgren V, Turunen JA, Forsblom C, Isomaa B, Groop PH, Groop L, Tuomi T. Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years. Diabetes Care 2010; 33(9): 2062-2064 doi: 10.2337/dc09-2188 pmid:20805278
|
41 |
Bakhtadze E, Cervin C, Lindholm E, Borg H, Nilsson P, Arnqvist HJ, Bolinder J, Eriksson JW, Gudbj?rnsdottir S, Nystr?m L, Agardh CD, Landin-Olsson M, Sundkvist G, Groop LC. Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients. Diabetologia 2008; 51(12): 2224-2232 doi: 10.1007/s00125-008-1161-2 pmid:18839133
|
42 |
Meierhoff G, Ott PA, Lehmann PV, Schloot NC. Cytokine detection by ELISPOT: relevance for immunological studies in type 1 diabetes. Diabetes Metab Res Rev 2002; 18(5): 367-380 doi: 10.1002/dmrr.320 pmid:12397579
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