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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

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Front Med    2012, Vol. 6 Issue (3) : 243-247    https://doi.org/10.1007/s11684-012-0201-y
REVIEW
Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection
Yu Liao, Yufei Xiang, Zhiguang Zhou()
Diabetes Center, 2nd Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha 410011, China
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Abstract

Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and age of diagnosis. Besides, β cell function, metabolic parameters, genetic factors and cell immunity may also contribute to the formulation of the criteria. Here, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.
Keywords LADA      diagnostic criteria      autoantibodies      insulin independence      age of diagnosis     
Corresponding Author(s): Zhou Zhiguang,Email:zhouzg@hotmail.com   
Issue Date: 05 September 2012
 Cite this article:   
Yu Liao,Yufei Xiang,Zhiguang Zhou. Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection[J]. Front Med, 2012, 6(3): 243-247.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-012-0201-y
https://academic.hep.com.cn/fmd/EN/Y2012/V6/I3/243
Research groupDiagnostic criteria
AutoantibodiesAgeInsulin-independenceOther aspects
Pan et al. (1997)GADA20-48 years oldNoneObvious polyphagia, weight loss at disease onset; BMI≤25; FPG≥16.5 mmol/L, FCP ≤ 0.4 nmol/L, 1 h PCP ≤ 0.8 nmol/L, 2 h PCP ≤ 0.8 nmol/L; existence of susceptible HLA-DQB1 gene
Zhou et al. (1997)GADA, ICA and/or IAA>15 years oldWithout ketosis in 6 months of onset of diabetesNon-obese at disease onset, along with organ-specific autoantibodies; existence of susceptible genes of T1DM, excluding MDM and MODY
Chi et al. (2006)GADA≤40 years OldNoneOvert symptoms, ketosis, no chronic complications or hypertension, BMI<18.5 kg/m2, FBG≥18.5 mmol/L and FCP<0.30 nmol/L
Zhou et al. (2011)GADA, IAA, IA-2A, ZnT8A≥18 years OldInsulin independence for at least 6 months after diagnosisNone
IDS (2004)ICA, GADA, IA-2A≥30 years oldInsulin independence for at least 6 months after diagnosisNone
Tab.1  Diagnostic criteria of LADA in China and IDS (2004)
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