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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2013, Vol. 7 Issue (2) : 223-230     DOI: 10.1007/s11684-013-0252-8
REVIEW |
The role of microRNAs in adipocyte differentiation
Rong Zhang, Di Wang, Zhuying Xia, Chao Chen, Peng Cheng, Hui Xie, Xianghang Luo()
Institute of Endocrinology & Metabolism, The Second Xiangya Hospital of Central South University, Changsha 410011, China
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Abstract  

Adipocytes differentiate from mesenchymal stem cells (MSCs) in a process known as adipogenesis. The programme of adipogenesis is regulated by the sequential activation of transcription factors and several signaling pathways. There is growing evidence indicating that a class of small non-coding single-stranded RNAs known as “microRNAs (miRNAs)” also are involved in this process. In this review, we summarize the biology and functional mechanisms of miRNAs in adipocyte differentiation. In addition, we further discuss the miRNAs profiling, the miRNAs function and miRNAs target prediction in the adipogenesis.

Keywords microRNA      adipocyte      differentiation      adipogenesis     
Corresponding Authors: Luo Xianghang,Email:xianghangluo@yahoo.cn   
Issue Date: 05 June 2013
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-013-0252-8     OR     http://academic.hep.com.cn/fmd/EN/Y2013/V7/I2/223
Fig.1  miRNAs are involved in the regulation of adipogenesis and osteogenesis. Mesenchymal stem cells are multipontent, being able to commit not only to preadipocytes, but also to preosteoblasts, premyoblasts and prechondrocytes (not shown). Some miRNAs identified as differential regulators in adipogenesis and osteogenesis are shown.
miRNAFunctionsTargetsReferences
miR-143miR-17-92miR-103miR-21miR-519dmiR-200miR-210miR-30miR204/211miR-375miR-27miR-130Let-7miR-448↑Adipogenesis↑Adipogenesis↑Adipogenesis↑Adipogenesis↑Adipogenesis↑Adipogenesis↑Adipogenesis↑Adipogenesis↑Adipogenesis↑Adipogenesis↓Adipogenesis↓Adipogenesis↓Adipogenesis↓AdipogenesisERK5RB2/ P130-TGFBR2 , STAT3PPARα-TCF7L2RUNX2RUNX2-PPARγPPARγHMGA2KLF5 [30,31,46] [47-50] [31] [51,52] [53] [55] [56] [57] [58] [59] [60-62] [63] [64] [66]
Tab.1  miRNA associated with adipogenesis in mammals
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