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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2013, Vol. 7 Issue (2) : 150-156     DOI: 10.1007/s11684-013-0267-1
Progress on molecular biomarkers and classification of malignant gliomas
Chuanbao Zhang1, Zhaoshi Bao1, Wei Zhang1, Tao Jiang1,2()
1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; 2. Beijing Neurosurgical Institute, Beijing 100050, China
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Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.

Keywords malignant glioma      molecular biomarker      IDH1      MGMT      molecular classification     
Corresponding Authors: Jiang Tao,   
Issue Date: 05 June 2013
URL:     OR
IDH1 mutation
MGMT promoter methylation
LOH of 1p/19q
Tab.1  Summary of diagnostic, prognostic, and predictive values of three distinct markers
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