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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2015, Vol. 9 Issue (1) : 20-29     DOI: 10.1007/s11684-014-0371-x
REVIEW |
Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
Yingchen Li1,Guoheng Hu2,*(),Qilai Cheng1
1. Post-Graduate School, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
2. Department of Neurology, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, China
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Abstract  

Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.

Keywords cellular therapy      transplantation      human umbilical cord      mesenchymal stem cells      ischemic stroke     
Corresponding Authors: Guoheng Hu   
Just Accepted Date: 24 October 2014   Online First Date: 02 February 2015    Issue Date: 02 March 2015
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-014-0371-x     OR     http://academic.hep.com.cn/fmd/EN/Y2015/V9/I1/20
Categories Positive Negative
Adhesion molecule CD166, CD54, CD102, CD58, CD56, CD44, CD106 CD62P, CD31
Growth factors and cytokine receptors CD121, CD123, CD126, CD127, CDw119, CD120a, CD140a CD25
Integrin families CD49a, CD49b, CD29, CD104 CD11a and CD11b
Other molecules SH2, SH3, SH4, Thy1(CD90), CD73, CD105, CD146 CD34, CD45, CD80, CD86
Tab.1  Categories of surface markers expressed by hUC-MSCs
Fig.1  Potential therapeutic mechanisms of hUC-MSCs implantation for ischemic stroke: (1) replacement of damaged nervous cells; (2) promotion of endogenous neural cells; (3) secretion of neurotrophic factors; (4) induction of vascularization and angiogenesis; (5) reduction of apoptosis; (6) prevention of inflammatory effect.
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