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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2015, Vol. 9 Issue (3) : 344-349     DOI: 10.1007/s11684-015-0399-6
RESEARCH ARTICLE |
Pathogenesis sequences in Gejiu miners with lung cancer: an introduction
Li Bian1,Yonghua Ruan2,Liju Ma3,Hairong Hua2,Li Zhou4,Xiaoyu Tuo1,Zheyan Zhou5,Ting Li1,Shiyue Liu1,Kewei Jin2,*()
1. Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2. Department of Pathology, Kunming Medical University, Kunming 650031, China
3. Department of Clinical Medicine Research, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
4. Department of Oncology, The Seventh People’s Hospital of Shanghai, Shanghai 200137, China
5. Department of Pathology, The Third People’s Hospital of Yunnan Province, Kunming 650011, China
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Abstract  

Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significant occupational characteristics. Tissue samples from these miners presented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lung cancers, and hyperplasia and dysplasia of epithelial cells in peri-cancerous tissue. Carcinomas induced by Yunnan tin mine dust in the animal experiment underwent inflammation, fibroplasia, hyperplasia, dysplasia, and carcinogenesis of epithelial cells. A correlated and synergistic relationship was observed between bronchial epithelial cell transformation and fibroblast activation in vitro induced by mine dust. Fibroblast hyperplasia and activation are important factors that promote the transformation and carcinogenesis of epithelial cells. Our findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lung cancer, which can lead to lung fiber hyperplasia.

Keywords Yunnan tin mine      miners      lung cancer     
Corresponding Authors: Kewei Jin   
Just Accepted Date: 08 June 2015   Online First Date: 08 July 2015    Issue Date: 26 August 2015
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-015-0399-6     OR     http://academic.hep.com.cn/fmd/EN/Y2015/V9/I3/344
Fig.1  Mine dust deposition, clear fibroplasia, and fibrosis in peri-cancerous tissue. H&E stain 100×.
Fig.2  Alveolar type II epithelial hyperplasia and dysplasia and thickening of alveolar septum fiber. H&E stain 200×.
Fig.3  Excessive inflammation infiltration around the bronchioles at the early inhalation stage. H&E stain 200×.
Fig.4  Mine dust deposition following fibrosis hyperplasia; H&E stain 100×. Reprinted from Ref. [10] with permission.
Fig.5  Alveolar epithelia that show squamous metaplasia and dysplasia (★). H&E stain, 200×.
Fig.6  Squamous epithelial dysplasia and carcinoma in situ formation (★). H&E stain 200×.
Fig.7  ConA agglutination assay was positive in transformed epithelial cells exposed to mine dust. Inverted microscope 40×.
Fig.8  Anchorage-independent growth was positive in transformed epithelial cells exposed to mine dust (A) but negative in non-transformed epithelial cells (B). Inverted microscope 100×.
Fig.9  Immunohistochemical staining of α-SMA was positive in activated fibroblasts exposed to mine dust.
Fig.10  Induction of lung epithelial cell transformation and fibroblast activation by Yunnan tin mine dust and their interaction.
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