|
|
Efficacy and safety of perioperative parecoxib for acute postoperative pain treatment in children: a meta-analysis |
Xueshan Bu, Lei Yang, Yunxia Zuo() |
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China |
|
|
Abstract Perioperative parecoxib administration reduces postoperative pain, opioid consumption, and adverse events in adult patients. However, the efficacy and safety of parecoxib in children remain unclear. This meta-analysis included related published studies to address this concern. Eight databases in the literature until February 2015 were systematically explored to identify randomized controlled trials (RCTs) comparing perioperative parecoxib administration and placebo/standard treatments for acute postoperative pain in children. Primary outcomes were postoperative pain scores and adverse events. The Face, Legs, Activity, Crying, Consolability scale was used to score pain in children younger than 6 years, whereas the Visual Analog Scale was used in children older than 6 years. Secondary outcomes were sedation scores (measured using the Ramsay scale), agitation scores (measured using the Sedation-Agitation Scale), and opioid consumption. The methodological quality of RCTs was independently assessed in accordance with the “Risk of bias” of Cochrane Collaboration. Data were analyzed using Review Manager 5.2. Twelve RCTs involving 994 patients met the inclusion criteria. Compared with children who received placebo treatment, those who received parecoxib demonstrated lower early (2 h) and later (12 h) postoperative pain scores; lower incidence rates of postoperative nausea, vomiting, and agitation; higher early (1 h) postoperative sedation scores; and lower agitation scores. Similarly, children who received parecoxib had lower early (2 h) and later (12 h) postoperative pain scores, lower incidence rates of postoperative nausea and vomiting, and lower early (1 h) postoperative sedation scores compared with those who received standard treatments; however, these children showed no significant difference in agitation scores. Unfortunately, data on the effect of parecoxib on opioid consumption were insufficient. Overall, these results suggested that perioperative parecoxib administration was associated with less acute postoperative pain and fewer adverse events compared with placebo or standard treatments. Parecoxib administration also resulted in less emergence agitation compared with placebo treatment and less excessive sedation concern compared with standard treatments. However, the long-term effects, effects on opioid consumption, and patient satisfaction of parecoxib administration warrant further investigation.
|
Keywords
NSAID
cyclooxygenase 2 inhibitor
child
pain, postoperative
opioid
placebo
|
Corresponding Author(s):
Yunxia Zuo
|
Just Accepted Date: 31 August 2015
Online First Date: 23 September 2015
Issue Date: 26 November 2015
|
|
1 |
M Astuto, G Rosano, G Rizzo, N Disma, A Di Cataldo. Methodologies for the treatment of acute and chronic nononcologic pain in children. Minerva Anestesiol 2007; 73(9): 459–465
pmid: 17660739
|
2 |
S Dahmani, D Michelet, PS Abback, C Wood, C Brasher, Y Nivoche, J Mantz. Ketamine for perioperative pain management in children: a meta-analysis of published studies. Paediatr Anaesth 2011; 21(6): 636–652
https://doi.org/10.1111/j.1460-9592.2011.03566.x
pmid: 21447047
|
3 |
P Russell, BS von Ungern-Sternberg, SA Schug. Perioperative analgesia in pediatric surgery. Curr Opin Anaesthesiol 2013; 26(4): 420–427
https://doi.org/10.1097/ACO.0b013e3283625cc8
pmid: 23756911
|
4 |
AM Schultz-Machata, M Weiss, K Becke. What’s new in pediatric acute pain therapy? Curr Opin Anaesthesiol 2014; 27(3): 316–322
https://doi.org/10.1097/ACO.0000000000000074
pmid: 24709667
|
5 |
NS Morton, A Errera. APA national audit of pediatric opioid infusions. Paediatr Anaesth 2010; 20(2): 119–125
https://doi.org/10.1111/j.1460-9592.2009.03187.x
pmid: 19889193
|
6 |
M Niesters, F Overdyk, T Smith, L Aarts, A Dahan. Opioid-induced respiratory depression in paediatrics: a review of case reports. Br J Anaesth 2013; 110(2): 175–182
https://doi.org/10.1093/bja/aes447
pmid: 23248093
|
7 |
D Michelet, J Andreu-Gallien, T Bensalah, J Hilly, C Wood, Y Nivoche, J Mantz, S Dahmani. A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain. Anesth Analg 2012; 114(2): 393–406
https://doi.org/10.1213/ANE.0b013e31823d0b45
pmid: 22104069
|
8 |
SR Lewis, A Nicholson, ME Cardwell, G Siviter, AF Smith. Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy. Cochrane Database Syst Rev 2013; 7: CD003591
pmid: 23881651
|
9 |
MOE Hilário, MT Terreri, CA Len. Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors. J Pediatr (Rio J) 2006; 82(8 Suppl): S206–S212
https://doi.org/10.2223/JPED.1560
pmid: 17136297
|
10 |
P Jüni, L Nartey, S Reichenbach, R Sterchi, PA Dieppe, M Egger. Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 2004; 364(9450): 2021–2029
https://doi.org/10.1016/S0140-6736(04)17514-4
pmid: 15582059
|
11 |
R Lloyd, S Derry, RA Moore, HJ McQuay. Intravenous or intramuscular parecoxib for acute postoperative pain in adults. Cochrane Database Syst Rev 2009; (2): CD004771
pmid: 19370610
|
12 |
B Hullett, S Salman, SJ O’Halloran, D Peirce, K Davies, KF Ilett. Development of a population pharmacokinetic model for parecoxib and its active metabolite valdecoxib after parenteral parecoxib administration in children. Anesthesiology 2012; 116(5): 1124–1133
https://doi.org/10.1097/ALN.0b013e31825154ef
pmid: 22450476
|
13 |
RM Langford, GP Joshi, TJ Gan, MS Mattera, WH Chen, DA Revicki, C Chen, G Zlateva. Reduction in opioid-related adverse events and improvement in function with parecoxib followed by valdecoxib treatment after non-cardiac surgery: a randomized, double-blind, placebo-controlled, parallel-group trial. Clin Drug Investig 2009; 29(9): 577–590
https://doi.org/10.2165/11317570-000000000-00000
pmid: 19663520
|
14 |
J Graff, M Arabmotlagh, R Cheung, G Geisslinger, S Harder. Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. Clin Ther 2007; 29(3): 438–447
https://doi.org/10.1016/S0149-2918(07)80082-8
pmid: 17577465
|
15 |
Anonymous. Dynastat; MIMS abbreviated prescribing information. E-MIMS Ver 5.01.0100 2010; MultiMedia Australia Pty Limited, St Leonards, Australia
|
16 |
X Ding, X Chen. The influence of parecoxib on hemodynamics and emergence agitation after ketamine anesthesia in children. Jiangsu Med J (Jiangsu Yi Yao) 2012; 38(24): 3023–3024 (in Chinese)
|
17 |
ZW He. Parecoxib combined with dezocine for prevention emergence agitation after combined anesthesia with remifentanil and sevoflurane in children. Mod Hosp (Xian Dai Yi Yuan) 2014; 14(5): 40–42 (in Chinese)
|
18 |
RM Wang, XQ Chai, KZ Chen. The preemptive analgesia of dezocine in combination with parecoxib in children undergoing tonsillectomy. Anhui Med J (Anhui Yi Xue) 2014; 35(11): 1483–1485 (in Chinese)
|
19 |
PS Qin. The combination of parecoxib single IV injection with fentanyl PCA and for limbs operation in children. Wenzhou: Wenzhou Medical College, 2010 (in Chinese)
|
20 |
H Lv, J Li, HR Chen, YQ Liu, LB Xie, QF Cai, L Li. Effect of preemptive analgesia with Parecoxib sodium in children undergoing adenoidectomy. Chin J Clinicians (Zhonghua Lin Chuang Yi Shi Za Zhi) (Electronic Edition) 2012; 6(12): 3422–3423 (in Chinese)
|
21 |
PS Qin, MY Cai, J Li, JG Wang, QQ Lian. A clinical observation of single intravenous injection of parecoxib combined with fentanyl for postoperative pain management in children. Chin J. Chin J Clin Pharmacol Ther (Zhongguo Lin Chuang Yao Li Xue Yu Zhi Liao Xue) 2011; 16(9): 1021–1025 (in Chinese)
|
22 |
R Subramaniam, C Joshi, A Sharma, CN Prasad. Analgesic efficacy of single-dose parecoxib for corneal suturing in children. Eur J Anaesthesiol 2007; 24(5): 464–465
https://doi.org/10.1017/S0265021506001426
pmid: 17087840
|
23 |
YL Miao, WZ Shi, WZ Guo, J Zhong, WW Fang, J Liu, ZJ Wang, G Liu. Effect of preemptive analgesia with Parecoxib sodium in children undergoing endoscopic adenoidectomy and tonsillectomy of snoring disease. Clin J Med Offic (Lin Chuang Jun Yi Za Zhi) 2012; 40(2): 300–302 (in Chinese)
|
24 |
K Li, JZ Pan. Parecoxib prevents restlessness during waking- up from sevoflurane anesthesia in children. Mod Hosp (Xian Dai Yi Yuan) 2011; 11(2): 30–31(in Chinese)
|
25 |
CL Sun, XT Zhao, XZ Li. Different drugs’ effects on restlessness and pain after tonsillectomy in children. Theory Pract Med (Yi Xue Li Lun Yu Shi Jian) 2014; 27(9): 1127–1129(in Chinese)
|
26 |
XG Ma, XT Yan. The clinical observation of parecoxib in preemptive analgesia in the control of adenoid and tonsil surgery. J Hubei Univ Natly: Med Ed (Hubei Min Zu Xue Yuan Xue Bao: Yi Xue Ban) 2013; 30(3): 53–55(in Chinese)
|
27 |
XZ Li, W Li, Q Xia. Clinical study of preemptive analgesia with parecoxib sodium in children undergoing upper limb orthopedic surgery. West China Med J (Huaxi Yi Xue) 2011; 26(8): 1189–1191 (in Chinese)
|
28 |
YZ Zhang, Q Li, QX Liu. The use of parecoxib and tramadol in preemptive analgesia in laparoscopic hernia repair in children. J Clin Pediatr Surg (Lin Chuang Xiao Er Wai Ke Za Zhi) 2014; 13(3): 250–252 (in Chinese)
|
29 |
WL Ye, WN Jiang. Comparation of the efficacy of parecoxib and tramadol for corneal suturing in children. Strait Pharm J (Hai Xia Yao Xue) 2013; 25(7): 164–165 (in Chinese)
|
30 |
WJ Fan, N Wu, L Niu. The clinical observation of parecoxib in preemptive analgesia in hypospadias operation in children. Chin J Clin Res (Zhongguo Lin Chuang Yan Jiu) 2013; 26(12): 1358–1359 (in Chinese)
|
31 |
YX Yuan, WB Li, RY Gao, YJ Dong. Parecoxib combined with tramadol for prevention emergence agitation after general anesthesia in children. J Qiqihar Med Coll (Qiqihar Yi Xue Yuan Xue Bao) 2010; 31(11): 1729–1730 (in Chinese)
|
32 |
JPT Higgins, S Green. Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration, 2011 [2011-03].
|
33 |
D Moher, DJ Cook, S Eastwood, I Olkin, D Rennie, DF Stroup. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 1999; 354(9193): 1896–1900
https://doi.org/10.1016/S0140-6736(99)04149-5
pmid: 10584742
|
34 |
A Liberati, DG Altman, J Tetzlaff, C Mulrow, PC Gøtzsche, JP Ioannidis, M Clarke, PJ Devereaux, J Kleijnen, D Moher. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009; 339: b2700
https://doi.org/10.1136/bmj.b2700
pmid: 19622552
|
35 |
JA Sterne, AJ Sutton, JP Ioannidis, N Terrin, DR Jones, J Lau, J Carpenter, G Rücker, RM Harbord, CH Schmid, J Tetzlaff, JJ Deeks, J Peters, P Macaskill, G Schwarzer, S Duval, DG Altman, D Moher, JP Higgins. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 2011; 343: d4002
https://doi.org/10.1136/bmj.d4002
pmid: 21784880
|
36 |
PJ Desjardins, EH Grossman, ME Kuss, S Talwalker, S Dhadda, D Baum, RC Hubbard. The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively. Anesth Analg 2001; 93(3): 721–727
https://doi.org/10.1097/00000539-200109000-00036
pmid: 11524347
|
37 |
E Maund, C McDaid, S Rice, K Wright, B Jenkins, N Woolacott. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth 2011; 106(3): 292–297
https://doi.org/10.1093/bja/aeq406
pmid: 21285082
|
38 |
J Wetterslev, K Thorlund, J Brok, C Gluud. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol 2008; 61(1): 64–75
https://doi.org/10.1016/j.jclinepi.2007.03.013
pmid: 18083463
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|