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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2016, Vol. 10 Issue (2) : 143-151     DOI: 10.1007/s11684-016-0451-1
REVIEW |
Regeneration of hair cells in the mammalian vestibular system
Wenyan Li1,2,Dan You1,2,Yan Chen1,2,3,Renjie Chai4,5,*(),Huawei Li1,2,6,*()
1. Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China
2. Key Laboratory of Hearing Medicine of the National Health and Family Planning Commission, Shanghai 200031, China
3. Research Center, Affiliated Eye and ENT Hospital, Fudan University, Shanghai 200031, China
4. MOE Key Laboratory of Developmental Genes and Human Disease, State Key Laboratory of Bioelectronics, Institute of Life Sciences, Southeast University, Nanjing 210096, China
5. Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China
6. Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
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Abstract  

Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animals to recover from hearing and balance deficits. Such regeneration does not occur efficiently in humans and other mammals. Thus, balance deficits become permanent and is a common sensory disorder all over the world. Since Forge and Warchol discovered the limited spontaneous regeneration of vestibular hair cells after gentamicin-induced damage in mature mammals, significant efforts have been exerted to trace the origin of the limited vestibular regeneration in mammals after hair cell loss. Moreover, recently many strategies have been developed to promote the hair cell regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch and Atoh1. This article provides an overview of the recent advances in hair cell regeneration in mammalian vestibular epithelia. Furthermore, this review highlights the current limitations of hair cell regeneration and provides the possible solutions to regenerate functional hair cells and to partially restore vestibular function.

Keywords utricle      hair cell      regeneration      Atoh1      Notch      Wnt     
Corresponding Authors: Renjie Chai,Huawei Li   
Online First Date: 17 May 2016    Issue Date: 27 May 2016
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-016-0451-1     OR     http://academic.hep.com.cn/fmd/EN/Y2016/V10/I2/143
Fig.1  Schematic of hair cell regeneration via proliferation and transdifferentiation of recruited Lgr5+ progenitors following hair cell loss in mammalian utricle.
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