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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea |
Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang(),Renjie Chai() |
Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China |
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Abstract Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
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Keywords
inner ear
cochlea
hair cell
regeneration
Wnt
Notch
signaling pathways
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Corresponding Author(s):
Mingliang Tang,Renjie Chai
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Just Accepted Date: 19 July 2016
Online First Date: 12 August 2016
Issue Date: 30 August 2016
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