Please wait a minute...
Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2016, Vol. 10 Issue (4) : 507-516     DOI: 10.1007/s11684-016-0475-6
RESEARCH ARTICLE |
DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese
Wei Wang1,2,3,Ming Li1,2,Li Wang3,Xueqing Yu1,2()
1. Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
2. Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou 510080, China
3. Department of Nephrology, Sichuan Provincial People’s Hospital, Chengdu 610072, China
Download: PDF(129 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract  

Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibility. This study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibility and clinical manifestations of patients with IgAN in southern Han Chinese. A PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229 healthy subjects. Clinical data were collected from each patient at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects. High frequency of HLA-DQB1*060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy controls. Further stratification analysis revealed that the frequency of DQB1*060101 was significantly higher in patients with urine protein≥1.0 g/24 h than in patients with urine protein<1.0 g/24 h. In combination with our previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of HLA-DRB1*070101-DQB1*020101 was significantly lower (OR= 0.194, Pc = 0.016) compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility in Chinese Han population.

Keywords DQB1      human leukocyte antigen (HLA)      IgA nephropathy      haplotype      association study     
Corresponding Authors: Xueqing Yu   
Just Accepted Date: 19 October 2016   Online First Date: 23 November 2016    Issue Date: 01 December 2016
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-016-0475-6     OR     http://academic.hep.com.cn/fmd/EN/Y2016/V10/I4/507
Variable IgAN (n, total= 217) Healthy subjects (n, total= 229)
Age (year) 33.7±16.00 34.2±17.80
Sex
Male 91 (42.30%) 106 (46.40%)
Female 126 (57.70%) 123 (53.60%)
Blood pressure
Hypertension 54 (24.88%)
Norma blood pressure 163 (75.12%) 229 (100%)
Content of urine protein
≥1.0 g/24 h 80 (36.86%)
<1.0 g/24 h 137 (63.14%) Negative
Gross hematuria
Yes 70 (32.25%)
No 147 (67.75%) 229 (100%)
Serum IgA level
>3.45 mmol/L 61 (28.11%)
≤3.45 mmol/L 156 (71.89%)
Renal function
GFR≤60 ml/min 48 (22.11%)
GFR>60 ml/min 169 (77.89%) 229 (100%)
Crescent formation
Yes 59 (27.18%)
No 158 (72.82%) 229 (100%)
Tab.1  Basic clinical characteristics of IgAN patients
DQB1 allele IgAN
(Total= 217 × 2)
Control
(Total= 229 × 2)
c2 P OR 95% CI
n % n %
Lower Upper
*020101/0202 52 11.98 52 11.35 0.035 0.835 1.063 0.706 1.600
*030101/0309 52 11.98 93 20.30 10.139 0.001a 0.534 0.370 0.772
*030201 19 4.37 15 3.27 0.469 0.390 1.352 0.678 2.690
*030302 63 14.51 49 10.69 2.62 0.085 1.417 0.951 2.112
*0304 1 0.23 3 0.65 ND ND ND ND ND
*0310 2 0.46 1 0.21 ND ND ND ND ND
*0312 0 0 2 0.42 ND ND ND ND ND
*0401 18 4.14 13 2.83 0.782 0.361 1.481 0.717 3.061
*0402 7 1.61 6 1.31 0.100 0.784 1.235 0.412 3.704
*050101 15 3.45 17 3.71 0.010 0.859 0.929 0.458 1.883
*050201 58 13.36 80 17.46 2.564 0.096 0.729 0.505 1.052
*050202 2 0.46 4 0.87 0.932 0.687 0.525 0.096 2.884
*050301 25 5.76 34 7.42 0.747 0.347 0.762 0.447 1.300
*050302 2 0.46 3 0.65 ND ND ND ND ND
*0505 1 0.23 4 0.87 ND ND ND ND ND
*060101 90 20.73 51 11.13 14.725 <0.0001b 2.088 1.439 3.030
*0602 13 2.99 13 2.83 0 1 1.057 0.484 2.306
*0604 4 0.92 8 1.74 0.606 0.387 0.523 0.156 1.750
*060502 1 0.23 0 0 ND ND ND ND ND
*0609 9 2.07 10 2.18 0 0.910 0.949 0.382 2.358
Tab.2  Distribution of HLA-DQB1 allele frequencies in IgAN patients and healthy controls
DQB1 allele 24 h proteinuria>1 g
(Total= 80 × 2)
24 h proteinuria≤1 g
(Total= 137 × 2)
c2 P OR 95% CI
n % n % Lower Upper
*020101/0202 20 12.50 32 11.67 0.010 0.800 1.080 0.595 1.961
*030101/0309 14 8.75 38 13.86 2.048 0.106 0.596 0.312 1.137
*030201 5 3.12 14 5.10 0.535 0.330 0.599 0.212 1.695
*030302 22 13.75 41 14.96 0.042 0.728 0.906 0.518 1.585
*0304 1 0.62 0 0 ND ND ND ND ND
*0310 1 0.62 1 0.36 ND ND ND ND ND
*0401 6 3.75 12 4.37 0.005 0.749 0.851 0.313 2.312
*0402 3 1.87 4 1.45 0 0.712 1.129 0.285 5.838
*050101 7 4.37 8 2.91 0.584 0.391 2.14 0.425 10.779
*050201 13 8.12 45 16.42 5.213 0.011a 0.450 0.235 0.863
*050202 1 0.62 1 0.36 ND ND ND ND ND
*050301 9 5.62 16 5.83 0 0.926 0.961 0.415 2.28
*050302 0 0 2 0.72 ND ND ND ND ND
*0505 1 0.62 0 0 ND ND ND ND ND
*060101 48 30 42 15.32 12.351 <0.0001b 2.367 1.437 3.794
*0602 5 3.12 8 2.91 0 0.904 1.073 0.345 3.336
*060502 0 0 1 0.36 ND ND ND ND ND
*0604 0 0 4 1.45 ND ND ND ND ND
*0609 4 2.5 5 1.82 0.016 0.634 1.379 0.365 5.213
Tab.3  Distribution of HLA-DQB1 alleles in IgAN patients with 24 h proteinuria>1 g or≤1 g
DQB1 allele Crescent formation
(Total= 59 × 2)
No crescent formation
(Total= 158 × 2)
c2 P OR 95% CI
n % n % Lower Upper
*020101/0202 13 11.01 39 12.34 0.045 0.868 0.879 0.451 1.713
*030101/0309 10 8.47 42 13.29 1.461 0.156 0.604 0.293 1.247
*030201 5 4.23 14 4.43 0 0.93 0.954 0.336 2.711
*030302 13 11.01 50 15.82 1.235 0.224 0.659 0.344 1.263
*0304 0 0 1 0.31 ND ND ND ND ND
*0310 0 0 2 0.62 ND ND ND ND ND
*0401 13 11.01 5 1.58 16.917 <0.0001a 7.701 2.682 22.114
*0402 3 2.54 4 1.26 0.261 0.369 2.035 0.449 9.231
*050101 9 7.62 6 1.89 6.820 0.007b 4.266 1.484 12.262
*050201 17 14.40 41 12.97 0.054 0.698 1.129 0.614 2.077
*050202 1 0.84 1 0.31 ND ND ND ND ND
*050301 5 4.23 20 6.32 0.361 0.391 0.655 0.24 1.787
*050302 0 0 2 0.62 ND ND ND ND ND
*0505 1 0.84 0 0 ND ND ND ND ND
*060101 22 18.64 68 21.51 0.275 0.507 0.836 0.489 1.428
*0602 4 3.38 9 2.84 0 0.771 1.197 0.361 3.963
*0604 0 0 4 1.26 ND ND ND ND ND
*060502 0 0 1 0.31 ND ND ND ND ND
*0609 2 1.69 7 2.21 0 0.730 0.761 0.156 3.717
Tab.4  Distribution of HLA-DQB1 alleles in IgAN patients with or without crescent formation
DQB1 allele Gross hematuria
(Total= 70 × 2)
No gross hematuria
(Total= 147 × 2)
c2 P OR 95% CI
n % n % Lower Upper
*020101/0202 18 12.85 34 11.56 0.053 0.698 1.128 0.613 2.077
*030101/0309 14 10 38 12.92 0.517 0.380 0.749 0.391 1.432
*030201 6 4.28 13 4.42 0 1 0.957 0.324 2.824
*030302 20 14.28 43 14.62 0 1 0.973 0.548 1.726
*0304 0 0 1 0.34 ND ND ND ND ND
*0310 0 0 2 0.68 ND ND ND ND ND
*0401 8 5.71 10 3.40 0.761 0.259 1.721 0.664 4.461
*0402 6 5.45 1 0.34 6.984 0.003a 13.119 1.564 110.051
*050101 6 4.28 9 3.06 0.138 0.514 1.418 0.495 4.065
*050201 18 12.85 40 13.6 0.004 0.830 0.937 0.516 1.702
*050202 0 0 2 0.68 ND ND ND ND ND
*050301 7 5 18 6.12 0.062 0.639 0.807 0.329 1.979
*050302 0 0 2 0.68 ND ND ND ND ND
*0505 0 0 1 0.34 ND ND ND ND ND
*060101 31 22.14 59 20.06 0.318 0.618 1.133 0.694 1.850
*0602 2 1.42 11 3.74 1.041 0.186 0.373 0.082 1.705
*0604 0 0 4 1.22 ND ND ND ND ND
*060502 1 0.71 0 0 ND ND ND ND ND
*0609 3 2.14 6 2.04 0 0.944 1.051 0.259 4.266
Tab.5  Distribution of HLA-DQB1 alleles in IgAN patients with or without gross hematuria
DQB1 allele Hypertension
(Total= 54 × 2)
Normal blood pressure
(Total= 163 × 2)
c2 P OR 95% CI
n % n % Lower Upper
*020101/0202 8 7.40 44 13.49 2.304 0.123 0.513 0.233 1.126
*030101/0309 10 9.25 42 12.88 0.696 0.315 0.690 0.334 1.427
*030201 3 2.77 16 4.90 0.444 0.348 0.554 0.158 1.938
*0304 0 0 1 0.30 ND ND ND ND ND
*030302 20 18.51 43 13.19 1.452 0.173 1.496 0.836 2.677
*0310 0 0 2 0.61 ND ND ND ND ND
*0401 3 2.77 15 4.60 0.297 0.410 0.592 0.168 2.087
*0402 0 0 7 2.14 ND ND ND ND ND
*050101 4 3.70 11 3.37 0 0.871 1.101 0.343 3.533
*050201 16 14.81 42 12.88 0.121 0.609 1.176 0.631 2.190
*050202 2 1.85 0 0 ND ND ND ND ND
*050301 5 4.62 20 6.13 0.118 0.552 0.743 0.272 2.029
*050302 1 0.92 1 0.30 ND ND ND ND ND
*0505 0 0 1 0.30 ND ND ND ND ND
*060101 29 26.85 61 18.71 2.794 0.076 1.595 0.959 2.652
*0602 3 2.77 10 3.06 0 0.878 0.903 0.244 3.343
*060502 1 0.92 0 0 ND ND ND ND ND
*0604 1 0.92 3 0.92 ND ND ND ND ND
*0609 2 1.85 7 2.14 0 0.852 0.860 0.176 4.203
Tab.6  Distribution of HLA-DQB1 alleles in IgAN patients with hypertension or normal blood pressure
DQB1 allele Serum IgA>3.45 mmol/L
(Total= 61 × 2)
Serum IgA≤3.45 mmol/L
(Total= 156 × 2)
c2 P OR 95% CI
n % n % Lower Upper
*020101/0202 11 9.01 41 13.14 1.051 0.255 0.655 0.325 1.321
*030101/0309 14 11.47 38 12.17 0.001 1 0.935 0.487 1.794
*030201 5 4.09 14 4.48 0 0.858 0.91 0.32 2.582
*030302 25 20.49 38 12.17 4.237 0.032 1.858 1.067 3.238
*0304 0 0 1 0.32 ND ND ND ND ND
*0310 1 0.81 1 0.32 ND ND ND ND ND
*0401 6 4.91 12 3.84 0.056 0.599 1.293 0.474 3.526
*0402 2 1.63 5 1.6 0 0.978 1.023 0.196 5.346
*050101 6 4.91 9 2.88 0.563 0.313 1.741 0.606 5.001
*050201 14 11.47 44 14.1 0.321 0.532 0.79 0.416 1.5
*050202 2 1.63 0 0 ND ND ND ND ND
*050301 8 6.55 17 5.44 0.047 0.660 1.218 0.511 2.900
*050302 0 0 2 0.64 ND ND ND ND ND
*0505 1 0.81 0 0 ND ND ND ND ND
*060101 20 16.39 70 22.43 1.598 0.155 0.678 0.392 1.173
*0602 4 3.27 9 2.88 0 0.763 1.141 0.345 3.777
*0604 1 0.81 3 0.96 ND ND ND ND ND
*060502 0 0 1 0.32 ND ND ND ND ND
*0609 2 1.63 7 2.24 0.001 0.684 0.726 1.149 3.545
Tab.7  Distribution of HLA-DQB1 alleles in IgAN patients with serum IgA>3.45 or≤3.45 mmol/L
DQB1 allele eGFR≤60 ml/min/1.73m2
(Total= 48 × 2)
eGFR>60 ml/min/1.73m2
(Total= 169 × 2)
c2 P OR 95% CI
n % n % Lower Upper
*020101/0202 8 8.33 44 13.01 1.143 0.196 0.607 0.276 1.339
*030101/0309 12 12.5 40 11.83 0 0.861 1.064 0.534 2.120
*030201 5 5.20 14 4.14 0.028 0.659 1.272 0.446 3.624
*030302 18 18.75 45 13.31 1.370 0.193 1.503 0.824 2.740
*0304 0 0 1 0.29 ND ND ND ND ND
*0310 1 1.04 1 0.29 ND ND ND ND ND
*0401 5 5.20 13 3.84 0.09 0.564 1.374 0.477 3.954
*0402 2 2.08 5 1.47 0 0.708 1.383 0.264 7.243
*050101 4 4.16 11 3.25 0.013 0.673 1.292 0.402 4.154
*050201 14 14.58 44 13.01 0.052 0.734 1.141 0.596 2.184
*050202 1 1.04 1 0.29 ND ND ND ND ND
*050301 6 6.25 19 5.62 0 0.806 1.119 0.434 2.886
*050302 0 0 2 0.58 ND ND ND ND ND
*0505 0 0 1 0.29 ND ND ND ND ND
*060101 14 14.58 76 22.48 0.829 0.377 0.717 0.386 1.332
*0602 4 4.16 9 2.66 2.380 0.082 5.89 0.316 1.096
*0604 0 0 4 1.18 ND ND ND ND ND
*060502 0 0 1 0.29 ND ND ND ND ND
*0609 2 2.08 7 2.07 0 1 1.006 0.206 4.924
Tab.8  Distribution of HLA-DQB1 alleles in IgAN patients with eGFR≤60 or>60 ml/min/ 1.73 m2
DRB1-DQB1 IgAN patients
(Total = 139)
(278 alleles)
Healthy subjects
(Total= 143)
(286 alleles)
P OR 95% CI
n % n % Lower Upper
*030101-020101 6 2.15 9 3.14 0.603 0.679 0.238 1.933
*070101-020101 4 1.43 20 6.99 0.001a 0.194 0.065 0.576
*070101-030302 2 0.71 10 3.49 0.046 0.200 0.043 0.921
*080302-060101 12 4.31 14 4.89 0.842 0.876 0.398 1.930
*090102-030101 7 2.51 15 5.24 0.146 0.467 0.187 1.163
*090102-060101 24 8.63 6 2.09 0.001b 4.409 1.774 10.961
*090102-030302 6 2.15 8 2.79 0.828 0.767 0.263 2.238
*110101-050101 7 2.51 8 2.79 1.000 0.898 0.321 2.509
*120101-030101 2 0.71 8 2.79 0.107 0.252 0.053 1.196
*140101-050301 5 1.79 9 3.14 0.448 0.564 0.187 1.703
*140101-050201 3 1.07 10 3.49 0.103 0.301 0.082 1.106
*140501-020101 7 2.51 12 4.19 0.384 0.590 0.229 1.521
*150101-030302 14 5.03 12 4.19 0.783 1.211 0.550 2.666
*150101-060101 10 3.59 6 2.09 0.413 1.741 0.624 4.857
*150101-0602 6 2.15 10 3.49 0.482 0.609 0.218 1.698
*160201-050201 4 1.43 8 2.79 0.383 0.507 0.151 1.704
Others 159 121
Tab.9  HLA-DRB1-DQB1 haplotypes in IgAN patients and healthy controls
1 Barratt J, Feehally J. IgA nephropathy. J Am Soc Nephrol 2005; 16(7): 2088–2097
doi: 10.1681/ASN.2005020134 pmid: 15930092
2 Donadio JV, Grande JP. IgA nephropathy. N Engl J Med 2002; 347(10): 738–748
doi: 10.1056/NEJMra020109 pmid: 12213946
3 Mestecky J, Raska M, Julian BA, Gharavi AG, Renfrow MB, Moldoveanu Z, Novak L, Matousovic K, Novak J. IgA nephropathy: molecular mechanisms of the disease. Annu Rev Pathol 2013; 8(8): 217–240
doi: 10.1146/annurev-pathol-011110-130216 pmid: 23092188
4 Szeto CC, Lai FM, To KF, Wong TY, Chow KM, Choi PC, Lui SF, Li PK. The natural history of immunoglobulin a nephropathy among patients with hematuria and minimal proteinuria. Am J Med 2001; 110(6): 434–437
doi: 10.1016/S0002-9343(01)00659-3 pmid: 11331053
5 Rantala I, Mustonen J, Hurme M, Syrjänen J, Helin H. Pathogenetic aspects of IgA nephropathy. Nephron 2001; 88(3): 193–198
doi: 10.1159/000045989 pmid: 11423748
6 Hsu SI, Ramirez SB, Winn MP, Bonventre JV, Owen WF. Evidence for genetic factors in the development and progression of IgA nephropathy. Kidney Int 2000; 57(5): 1818–1835
doi: 10.1046/j.1523-1755.2000.00032.x pmid: 10792601
7 Maxwell PH, Wang Y. Genetic studies of IgA nephropathy. Nephron, Exp Nephrol 2006; 102(3-4): e76–e80
doi: 10.1159/000089685 pmid: 16282702
8 Horton R, Wilming L, Rand V, Lovering RC, Bruford EA, Khodiyar VK, Lush MJ, Povey S, Talbot CC Jr, Wright MW, Wain HM, Trowsdale J, Ziegler A, Beck S. Gene map of the extended human MHC. Nat Rev Genet 2004; 5(12): 889–899
doi: 10.1038/nrg1489 pmid: 15573121
9 Floege J, Feehally J. IgA nephropathy: recent developments. J Am Soc Nephrol 2000; 11(12): 2395–2403
pmid: 11095664
10 Cao HX, Li M, Nie J, Wang W, Zhou SF, Yu XQ. Human leukocyte antigen DRB1 alleles predict risk and disease progression of immunoglobulin A nephropathy in Han Chinese. Am J Nephrol 2008; 28(4): 684–691
doi: 10.1159/000122111 pmid: 18367833
11 Feehally J, Farrall M, Boland A, Gale DP, Gut I, Heath S, Kumar A, Peden JF, Maxwell PH, Morris DL, Padmanabhan S, Vyse TJ, Zawadzka A, Rees AJ, Lathrop M, Ratcliffe PJ. HLA has strongest association with IgA nephropathy in genome-wide analysis. J Am Soc Nephrol 2010; 21(10): 1791–1797 doi:10.1681/ASN.2010010076 PMID:20595679
12 Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I, Savoldi S, Magistroni R, Ghiggeri GM, Bodria M, Lugani F, Ravani P, Ponticelli C, Allegri L, Boscutti G, Frasca G, Amore A, Peruzzi L, Coppo R, Izzi C, Viola BF, Prati E, Salvadori M, Mignani R, Gesualdo L, Bertinetto F, Mesiano P, Amoroso A, Scolari F, Chen N, Zhang H, Lifton RP. Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat Genet 2011; 43(4): 321–327
doi: 10.1038/ng.787 pmid: 21399633
13 Yu XQ, Li M, Zhang H, Low HQ, Wei X, Wang JQ, Sun LD, Sim KS, Li Y, Foo JN, Wang W, Li ZJ, Yin XY, Tang XQ, Fan L, Chen J, Li RS, Wan JX, Liu ZS, Lou TQ, Zhu L, Huang XJ, Zhang XJ, Liu ZH, Liu JJ. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. Nat Genet 2012; 44(2): 178–182
doi: 10.1038/ng.1047 pmid: 22197929
14 Kiryluk K, Li Y, Scolari F, Sanna-Cherchi S, Choi M, Verbitsky M, Fasel D, Lata S, Prakash S, Shapiro S, Fischman C, Snyder HJ, Appel G, Izzi C, Viola BF, Dallera N, Del Vecchio L, Barlassina C, Salvi E, Bertinetto FE, Amoroso A, Savoldi S, Rocchietti M, Amore A, Peruzzi L, Coppo R, Salvadori M, Ravani P, Magistroni R, Ghiggeri GM, Caridi G, Bodria M, Lugani F, Allegri L, Delsante M, Maiorana M, Magnano A, Frasca G, Boer E, Boscutti G, Ponticelli C, Mignani R, Marcantoni C, Di Landro D, Santoro D, Pani A, Polci R, Feriozzi S, Chicca S, Galliani M, Gigante M, Gesualdo L, Zamboli P, Battaglia GG, Garozzo M, Maixnerová D, Tesar V, Eitner F, Rauen T, Floege J, Kovacs T, Nagy J, Mucha K, Pączek L, Zaniew M, Mizerska-Wasiak M, Roszkowska-Blaim M, Pawlaczyk K, Gale D, Barratt J, Thibaudin L, Berthoux F, Canaud G, Boland A, Metzger M, Panzer U, Suzuki H, Goto S, Narita I, Caliskan Y, Xie J, Hou P, Chen N, Zhang H, Wyatt RJ, Novak J, Julian BA, Feehally J, Stengel B, Cusi D, Lifton RP, Gharavi AG. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat Genet 2014; 46(11): 1187–1196
doi: 10.1038/ng.3118 pmid: 25305756
15 Li M, Foo JN, Wang JQ, Low HQ, Tang XQ, Toh KY, Yin PR, Khor CC, Goh YF, Irwan ID, Xu RC, Andiappan AK, Bei JX, Rotzschke O, Chen MH, Cheng CY, Sun LD, Jiang GR, Wong TY, Lin HL, Aung T, Liao YH, Saw SM, Ye K, Ebstein RP, Chen QK, Shi W, Chew SH, Chen J, Zhang FR, Li SP, Xu G, Tai ES, Wang L, Chen N, Zhang XJ, Zeng YX, Zhang H, Liu ZH, Yu XQ, Liu JJ. Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nat Commun 2015; 6: 7270
doi: 10.1038/ncomms8270 pmid: 26028593
16 Churg J, Bernstein J, Glassock RJ. WHO Monograph. Renal Disease Classification and Atlas of Glomerular Disease.4th ed. New York: Ikagu Shoin Medical Publishers Inc, 1995
17 Kotsch K, Wehling J, Blasczyk R. Sequencing of HLA class II genes based on the conserved diversity of the non-coding regions: sequencing based typing of HLA-DRB genes. Tissue Antigens 1999; 53(5): 486–497
doi: 10.1034/j.1399-0039.1999.530505.x pmid: 10372544
18 Lin JH, Liu ZH, Lv FJ, Fu YG, Fan XL, Li SY, Lu JM, Liu XY, Xu AL. Molecular analyses of HLA-DRB1, -DPB1, and-DQB1 in Jing ethnic minority of Southwest China. Hum Immunol 2003; 64(8): 830–834
doi: 10.1016/S0198-8859(03)00128-9 pmid: 12878363
19 He YL, Zong LL, Peng DX, Liu ZH, Lin JH, Xu AL. Association of HLA-DPB1 gene with endometriosis in women of Guangdong Province in China. J First Mil Med Univ (Di Yi Jun Yi Da Xue Xue Bao) 2002; 22(5): 432–433(in Chinese)
pmid: 12390706
20 Schneider S, Roessli D, Excoffier L. Arlequin Version 2000: A Software for Population Genetics Data Analysis. Geneva, Switzerland: Genetics and Biometry Laboratory, University of Geneva, 2000
21 Dean J, Dean A, Burton J. Public Domain Software For Epidemiology And Disease Surveillance. WHO AIDS Series, 1990
22 Xiang Y, Gao Y, Wang T. Application and comparison of meta and pooled analyses in the study of cancer epidemiology. Chin J Oncol (Zhonghua Zhong Liu Za Zhi) 1999; 21(5): 354–358 (in Chinese) PMID:11776573
23 Svejgaard A, Ryder LP. HLA and disease associations: detecting the strongest association. Tissue Antigens 1994; 43(1): 18–27
doi: 10.1111/j.1399-0039.1994.tb02291.x pmid: 8023317
24 Li PK, Burns AP, So AK, Pusey CD, Feehally J, Rees AJ. The DQw7 allele at the HLA-DQB locus is associated with susceptibility to IgA nephropathy in Caucasians. Kidney Int 1991; 39(5): 961–965
doi: 10.1038/ki.1991.121 pmid: 1676769
25 Fennessy M, Hitman GA, Moore RH, Metcalfe K, Medcraft J, Sinico RA, Mustonen JT, D’Amico G. HLA-DQ gene polymorphism in primary IgA nephropathy in three European populations. Kidney Int 1996; 49(2): 477–480
doi: 10.1038/ki.1996.67 pmid: 8821832
26 Park MH, Song EY, Ahn C, Oh KH, Yang J, Kang SJ, Lee HS. Two subtypes of hepatitis B virus-associated glomerulonephritis are associated with different HLA-DR2 alleles in Koreans. Tissue Antigens 2003; 62(6): 505–511
doi: 10.1046/j.1399-0039.2003.00141.x pmid: 14617034
27 Wu Y, Chen Y, Li L, Cao Y, Liu Z, Liu B, Du Z, Zhang Y, Chen S, Lin Z, Xu A. Polymorphic amino acids at codons 9 and 37 of HLA-DQB1 alleles may confer susceptibility to cervical cancer among Chinese women. Int J Cancer 2006; 118(12): 3006–3011
doi: 10.1002/ijc.21746 pmid: 16425277
28 Raguénès O, Mercier B, Clèdes J, Whebe B, Férec C. HLA class II typing and idiopathic IgA nephropathy (IgAN): DQB1*0301, a possible marker of unfavorable outcome. Tissue Antigens 1995; 45(4): 246–249
doi: 10.1111/j.1399-0039.1995.tb02447.x pmid: 7638860
29 Doxiadis II, De Lange P, De Vries E, Persijn GG, Claas FH. Protective and susceptible HLA polymorphisms in IgA nephropathy patients with end-stage renal failure. Tissue Antigens 2001; 57(4): 344–347
doi: 10.1034/j.1399-0039.2001.057004344.x pmid: 11380944
[1] Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen. U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population[J]. Front. Med., 2015, 9(4): 478-486.
[2] Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG, . Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma[J]. Front. Med., 2010, 4(4): 419-429.
[3] Wei-Li ZHANG MD, PhD, Ru-Tai HUI MD, PhD, . Genetics of ischemic and hemorrhagic stroke in Chinese population[J]. Front. Med., 2010, 4(1): 21-28.
[4] SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin. Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning[J]. Front. Med., 2007, 1(3): 320-326.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed