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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report |
Haiyan He, Ran An, Jian Hou, Weijun Fu() |
Myeloma and Lymphoma Center, Department of Hematology, Changzheng Hospital, Shanghai 200003, China |
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Abstract Arsenic trioxide (ATO), a component of the traditional Chinese medicine arsenic sublimate, promotes apoptosis and induces leukemic cell differentiation. Combined with all-trans-retinotic acid (ATRA), ATO has become the first-line induction therapy in treating acute promyelocytic leukemia (APL). The most common side effects of ATO include hepatotoxicity, gastrointestinal symptoms, water-sodium retention, and nervous system damage. In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who was treated with ATO. After taking 10 mg ATO daily for 6 days, she presented shortness of breath, myodynia, elevated creatine kinase, and acute renal insufficiency. This report describes the first case of ATO-induced rhabdomyolysis.
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Keywords
arsenic trioxide
APL
rhabdomyolysis
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Corresponding Author(s):
Weijun Fu
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Just Accepted Date: 16 March 2017
Online First Date: 13 April 2017
Issue Date: 01 June 2017
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