Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

doi:10.1007/s11684-017-0564-1

Front. Med.

2017, Vol. 11

Issue (3) : 333-339 https://doi.org/10.1007/s11684-017-0564-1

REVIEW

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

Jian Liu, Weiming Wang(

)

Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

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Abstract

Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.

Keywords nephrotic syndrome focal segmental glomerulosclerosis genetic

Corresponding Author(s): Weiming Wang

Just Accepted Date: 18 July 2017 Online First Date: 04 August 2017 Issue Date: 29 August 2017

Cite this article:

Jian Liu,Weiming Wang. Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis[J]. Front. Med., 2017, 11(3): 333-339.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-017-0564-1
https://academic.hep.com.cn/fmd/EN/Y2017/V11/I3/333

Tab.1 Genetic causes of adult-onset FSGS/nephrotic syndrome

Fig.1 Causing genes for adult-onset FSGS/nephrotic syndrome.

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