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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2018, Vol. 12 Issue (1) : 76-83    https://doi.org/10.1007/s11684-017-0609-5
REVIEW
Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology for tuberculosis control
Chongguang Yang1,2, Qian Gao1()
1. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Science, Fudan University, Shanghai 200032, China
2. Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, 60 College Street, New Haven, CT 06510, USA
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Abstract

Tuberculosis (TB) has remained an ongoing concern in China. The national scale-up of the Directly Observed Treatment, Short Course (DOTS) program has accelerated the fight against TB in China. Nevertheless, many challenges still remain, including the spread of drug-resistant strains, high disease burden in rural areas, and enormous rural-to-urban migrations. Whether incident active TB represents recent transmission or endogenous reactivation has helped to prioritize the strategies for TB control. Evidence from molecular epidemiology studies has delineated the recent transmission of Mycobacterium tuberculosis (M. tuberculosis) strains in many settings. However, the transmission patterns of TB in most areas of China are still not clear. Studies carried out to date could not capture the real burden of recent transmission of the disease in China because of the retrospective study design, incomplete sampling, and use of low-resolution genotyping methods. We reviewed the implementations of molecular epidemiology of TB in China, the estimated disease burden due to recent transmission of M. tuberculosis strains, the primary transmission of drug-resistant TB, and the evaluation of a feasible genotyping method of M. tuberculosis strains in circulation.

Keywords tuberculosis      recent transmission      molecular epidemiology      China     
Corresponding Author(s): Qian Gao   
Just Accepted Date: 30 November 2017   Online First Date: 11 January 2018    Issue Date: 06 February 2018
 Cite this article:   
Chongguang Yang,Qian Gao. Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology for tuberculosis control[J]. Front. Med., 2018, 12(1): 76-83.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-017-0609-5
https://academic.hep.com.cn/fmd/EN/Y2018/V12/I1/76
Publications Duration of sampling Sampling strategy Settings No. of cases Genotyping method Clustering rate* Proportion of Beijing strain Risk factors
Li et al., 2016 [35] 1 year ND Hebei Province 1017 Spoligotyping+ 15-VNTR 25% 90% ND
Hu et al., 2015 [31] 3 years Population based Four rural counties from multiple provinces 1332 Spoligotyping+ 24-VNTR+ 4 highly variable loci 14% 75% ND
Yang et al., 2015 [28] 3 years Population based Five provincial counties across China 2274 VNTR (9+ 3), including 4 highly variable loci 31% 72% Beijing family, MDR strains
Lu et al., 2014 [33] 3 months Enrolled consecutively 30 counties in Jiangsu Province 497 Spoligotyping+ 15-VNTR (new) 27% 81% ND
Wang et al., 2014 [32] 18 months Population based Six cities in Eastern China 1222 7-VNTR
+ RFLP-61110
15% ND MDR strains
Tian et al., 2012 [34] 3 years ND Gansu Province in Northwest China 218 12-MIRU-VNTR 55% 86% ND
Yang et al., 2012 [29] 2 years Population based Six provincial counties across China 1375 16-VNTR 28% 75% ND
Hu et al., 2009 [30] 1 year Cross-sectional Two counties in Eastern China 351 12-MIRU-VNTR+ RFLP-6110 23% 69% ND
Tab.1  General characteristics of the molecular epidemiology studies
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