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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2018, Vol. 12 Issue (1) : 84-91    https://doi.org/10.1007/s11684-017-0612-x
RESEARCH ARTICLE |
Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey
N.V. Vasilyeva1,2,3(), E.R. Raush1, M.V. Rudneva2, T.S. Bogomolova1,2, A.E. Taraskina2, Yong Fang3, Fengmin Zhang3, N.N. Klimko4
1. Department of Medical Microbiology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg 194291, Russia
2. Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg 194291, Russia
3. Sino-Russia Institute of Infection and Immunity, Department of Microbiology, Harbin Medical University, Harbin 150086, China
4. Department of Clinical Mycology, Allergy and Immunology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg 194291, Russia
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Abstract

A multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was conducted in Russia in the period of 2012–2014. Samples were collected from 284 patients with invasive candidosis and Candida species isolated by culture. The species were identified by DNA sequencing and MALDI-TOF mass-spectrometry. A total of 322 isolates were recovered, in which 96% of Сandida species belonged to six major species, namely, C. albicans (43.2%), C. parapsilosis (20.2%), C. glabrata (11.5%), C. tropicalis (9.6%), C. krusei (6.2%), and C. guilliermondii (5.3%). Most Candida species were isolated from blood samples (83.23%). Notably, the prevalence rate of C. albicans reduced from 52.38% to 32.79% (2012 vs. 2014) (P=0.01) whereas that of non-C. albicans increased from 47.62% (2012) to 67.21% (2014) (P<0.01). Species distribution differed among geographical regions; specifically, the prevalence rate of C. albicans as an etiologic agent of invasive candidosis in Siberian Federal region was significantly higher than that in other Federal regions. Results indicated a shift from C. albicans to non-C. albicans. Therefore, a detailed investigation on the contributing factors and appropriate treatment of invasive candidosis is needed.

Keywords prevalence      Сandida species      invasive candidosis      nosocomial      etiology      MALDI-TOF mass-spectrometry      candidemia     
Corresponding Authors: N.V. Vasilyeva   
Just Accepted Date: 12 December 2017   Online First Date: 15 January 2018    Issue Date: 06 February 2018
 Cite this article:   
N.V. Vasilyeva,E.R. Raush,M.V. Rudneva, et al. Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey[J]. Front. Med., 2018, 12(1): 84-91.
 URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-017-0612-x
http://academic.hep.com.cn/fmd/EN/Y2018/V12/I1/84
Fig.1  Mass-spectrum profiles of six main Candida species: (A) C. albicans, (B) C. guilliermondii, (C) C. krusei, (D) C. tropicalis, (E) C. parapsilosis, and (F) C. glabrata.
Fig.2  Isolation rate of Candida species in Russia.
Fig.3  Isolation rate of Candida species from different samples.
Fig.4  Prevalence rate of six main Candida species from 2012 to 2014.
Fig.5  Etiology of invasive candidosis in different Federal regions of Russia (n=322).
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