LETTER TO FRONTIERS OF MEDICINE |
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Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis |
Jing Yue1, Bo Zhang1, Mingyue Wang1, Junning Yao1, Yifan Zhou1, Ding Ma2, Lei Jin1() |
1. Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2. Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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Abstract This retrospective study aims to demonstrate the effect of antitubercular treatment (ATT) on the pregnancy outcomes and prognoses of patients with genital tuberculosis (GTB) who had received laparoscopy and/or hysteroscopy. This study included 78 patients with infertility and who were diagnosed with GTB through laparoscopy and/or hysteroscopy over the period of November 2005 to October 2015. The recruited patients were divided into ATT and nonATT groups on the basis of ATT duration. The GTB recurrence rates, menstrual patterns, and pregnancy outcomes of the patients were determined at follow-up. Among the 78 patients, 46 received ATT and 32 did not receive ATT. The menstrual volumes of patients in the ATT group significantly decreased relative to those of patients in the nonATT group. GTB did not recur among all patients regardless of treatment. A total of 11 pregnancies (36.7%) in the ATT group and 19 pregnancies (63.3%) in the nonATT group were observed. Pregnancy rates significantly differed (P = 0.002) between the two groups. ATT may decrease the menstrual volume and pregnancy rates of patients who were diagnosed with GTB through laparoscopy and/or hysteroscopy. In addition, ATT did not improve the prognosis of patients with chronic GTB.
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Keywords
antitubercular treatment
pregnancy
prognosis
genital tuberculosis
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Corresponding Author(s):
Lei Jin
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Just Accepted Date: 24 April 2018
Online First Date: 27 June 2018
Issue Date: 12 March 2019
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1 |
GSchaefer. Female genital tuberculosis. Clin Obstet Gynecol 1976; 19(1): 223–239
https://doi.org/10.1097/00003081-197603000-00016
pmid: 1082803
|
2 |
PKMalkani, CK Rajani. Pelvic tuberculosis. Obstet Gynecol 1959; 14: 600–611
pmid: 14420334
|
3 |
ATinelli, A Malvasi, DVergara, RMartignago, GNicolardi, RTinelli, MPellegrino. Abdominopelvic tuberculosis in gynaecology: laparoscopical and new laboratory findings. Aust N Z J Obstet Gynaecol 2008; 48(1): 90–95
https://doi.org/10.1111/j.1479-828X.2007.00800.x
pmid: 18275578
|
4 |
UNJindal, Y Bala, SSodhi, SVerma, SJindal. Female genital tuberculosis: early diagnosis by laparoscopy and endometrial polymerase chain reaction. Int J Tuberc Lung Dis 2010; 14(12): 1629–1634
pmid: 21144250
|
5 |
MEftekhar, S Pourmasumi, PSabeti, AAflatoonian, MHSheikhha. Mycobacterium tuberculosis infection in women with unexplained infertility. Int J Reprod Biomed (Yazd) 2015; 13(12): 749–754
pmid: 27141534
|
6 |
VBhanothu, JP Theophilus, PKReddy, RRozati. Occurrence of female genital tuberculosis among infertile women: a study from a tertiary maternal health care research centre in South India. Eur J Clin Microbiol Infect Dis 2014; 33(11): 1937–1949
https://doi.org/10.1007/s10096-014-2164-1
pmid: 24894340
|
7 |
JBSharma, J Sneha, UBSingh, SKumar, KKRoy, N Singh, SDharmendra, PVanamail. Comparative study of laparoscopic abdominopelvic and fallopian tube findings before and after antitubercular therapy in female genital tuberculosis with infertility. J Minim Invasive Gynecol 2016; 23(2): 215–222
https://doi.org/10.1016/j.jmig.2015.09.023
pmid: 26455527
|
8 |
JBSharma, J Sneha, UBSingh, SKumar, KKRoy, N Singh, SDharmendra, ESharma, ASharma. Effect of antitubercular therapy on endometrial function in infertile women with female genital tuberculosis. Infect Disord Drug Targets 2016; 16(2):101–108
pmid: 26694016
|
9 |
IKNeonakis, DA Spandidos, EPetinaki. Female genital tuberculosis: a review. Scand J Infect Dis 2011; 43(8): 564–572
https://doi.org/10.3109/00365548.2011.568523
pmid: 21438789
|
10 |
RDeans, J Abbott. Review of intrauterine adhesions. J Minim Invasive Gynecol 2010; 17(5): 555–569
https://doi.org/10.1016/j.jmig.2010.04.016
pmid: 20656564
|
11 |
UNJindal, S Verma, YBala. Favorable infertility outcomes following anti-tubercular treatment prescribed on the sole basis of a positive polymerase chain reaction test for endometrial tuberculosis. Hum Reprod 2012; 27(5): 1368–1374
https://doi.org/10.1093/humrep/des076
pmid: 22419745
|
12 |
UNJindal, Y Bala, SSodhi, SVerma, SJindal. Female genital tuberculosis: early diagnosis by laparoscopy and endometrial polymerase chain reaction. Int J Tuberc Lung Dis 2010; 14(12): 1629–1634
pmid: 21144250
|
13 |
TRana, UB Singh, VKulshrestha, AKaushik, CPorwal, NAgarwal, AKriplani. Utility of reverse transcriptase PCR and DNA-PCR in the diagnosis of female genital tuberculosis. J Med Microbiol 2011; 60(Pt 4): 486–491
https://doi.org/10.1099/jmm.0.025080-0
pmid: 21183595
|
14 |
FRParikh, SG Nadkarni, SAKamat, NNaik, SB Soonawala, RMParikh. Genital tuberculosis — a major pelvic factor causing infertility in Indian women. Fertil Steril 1997; 67(3): 497–500
https://doi.org/10.1016/S0015-0282(97)80076-3
pmid: 9091337
|
15 |
VKulshrestha, A Kriplani, NAgarwal, UBSingh, TRana. Genital tuberculosis among infertile women and fertility outcome after antitubercular therapy. Int J Gynaecol Obstet 2011; 113(3): 229–234
https://doi.org/10.1016/j.ijgo.2010.12.014
pmid: 21457984
|
16 |
ECaliskan, Y Cakiroglu, KSofuoglu, EDoger, MEAkar, SOOzkan. Effects of salpingectomy and antituberculosis treatments on fertility results in patients with genital tuberculosis. J Obstet Gynaecol Res 2014; 40(10): 2104–2109
https://doi.org/10.1111/jog.12450
pmid: 25131900
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