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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

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Front. Med.    2019, Vol. 13 Issue (2) : 152-159    https://doi.org/10.1007/s11684-018-0628-x
REVIEW
Dental stem cell and dental tissue regeneration
Qiming Zhai1, Zhiwei Dong3, Wei Wang4, Bei Li1,2(), Yan Jin1,2()
1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, Fourth Military Medical University, Xi’an 710032, China
2. Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an 710032, China
3. Department of Oral and Maxillofacial Surgery, General Hospital of Shenyang Military Area Command, Shenyang 110840, China
4. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, Xi’an 710032, China
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Abstract

The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important function in mastication，, articulation，, and aesthetics. These characteristics, to a certain extent, greatly complicate the research in tooth regeneration. Recently, new ideas for tooth and tissue regeneration have begun to appear with rapid developments in the theories and technologies in tissue engineering. Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells (DPSCs), stem cells isolated from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs). All these cells can regenerate the tissue of tooth. This review outlines the cell types and strategies of stem cell therapy applied in tooth regeneration, in order to provide theoretical basis for clinical treatments.
Keywords stem cells      pulp regeneration      periodontal regeneration     
Corresponding Author(s): Bei Li,Yan Jin   
Just Accepted Date: 28 April 2018   Online First Date: 02 July 2018    Issue Date: 28 March 2019
 Cite this article:   
Qiming Zhai,Zhiwei Dong,Wei Wang, et al. Dental stem cell and dental tissue regeneration[J]. Front. Med., 2019, 13(2): 152-159.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-018-0628-x
https://academic.hep.com.cn/fmd/EN/Y2019/V13/I2/152
Types Tissue sources Markers Differentiation potency
DPSC Adult human dental pulp STRO-1, CD146 Odontoblast-like cells, osteoblasts, adipocytes, neural cells
SHED Pulp of exfoliated deciduous teeth STRO-1, CD146/MUC18, CD90, CD29, CD44, CD166, CD105, CD13 Odontoblasts, osteoblasts, adipocytes, neural cells
PDLSC Periodontal ligament STRO-1, CD146, CD73, CD90, CD105 Osteoblast-like cells, adipocytes, collagen-forming cells
SCAP Apical papilla STRO-1, CD146,CD24 Odontoblasts
DFC Dental follicle STRO-1, CD105, CD90, nestin, notch-1 Periodontal ligament cells, osteoblasts, cementoblasts
Tab.1  Characteristics of different types of dental stem cells
Fig.1  Cell aggregates of SPED regenerated pulp-like tissue in root canal of miniature pig. (A) Full-length root canal of pigs inserted with calcium hydroxide or cell aggregates. (B) H&E and Masson staining showed that pulp tissue was regenerated by SPED implantation after 3 months. In the control group, calcium hydroxide was inserted into young permanent incisors in miniature pigs (n = 3). After 3 months, no pulp tissue was regenerated and only calcium hydroxide was observed.
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