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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2019, Vol. 13 Issue (5) : 556-563    https://doi.org/10.1007/s11684-018-0649-5
REVIEW
Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice
Dan Luo1,2, Zhengyun Zuo3, Hongyan Zhao4, Yong Tan5, Cheng Xiao2()
1. Traditional Chinese Medicine Hospital of Changping District, Beijing 102200, China
2. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China
3. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
4. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100070, China
5. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100070, China
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Abstract

Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells; ratio of T cell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

Keywords Tripterygium wilfordii Hook F      immunoregulation      clinical studies     
Corresponding Author(s): Cheng Xiao   
Just Accepted Date: 16 November 2018   Online First Date: 02 January 2019    Issue Date: 14 October 2019
 Cite this article:   
Dan Luo,Zhengyun Zuo,Hongyan Zhao, et al. Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice[J]. Front. Med., 2019, 13(5): 556-563.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-018-0649-5
https://academic.hep.com.cn/fmd/EN/Y2019/V13/I5/556
Bioactive components Disease Action References Study design
TWP RA Serum TNF-α, IL-6↓ [13,14] RCT, RCT
RA Serum IL-1, TNF-α↓ [15] Non-RCT
RA Serum IL-10, sICAM-1↓ [16] RCT
RA Serum IL-1, IL-6, IL-8, TNF-α, Th1 cell ratio↓, Treg cell ratio↑ [17] RCT
RA Serum CCL5↓ [23] Non-RCT
GO Serum TNF-α, IL-2, IFN-γ↓, IL-10↑ [27] RCT
AAU Serum IL-2, TNF-α↓ [29] RCT
CD Foxp3+ Tregs, IL-10↑, TNF-α↓ from intestinal mucosa [30] Before–after study
CD Serum TNF-α, IL-1β↓ [31] Prospective study
Asthma CD4+ T cell ratio↓, CD8+ T cell ratio↑ [33] RCT
Asthma Serum IL-2, IL-4, IL-5↓ [34] Before–after study
Asthma IL-5, sIL-2R↓, eosinophil apoptotic rate↑ from sputum [35] RCT
Asthma IL-4, sIL-2R, sCD23, BRA↓, IFN-γ↑ from PBMCs [36] RCT
GBS Serum IL-6, CSF IL-6, sIL-2R, Syn IgG↓ [37, 38] RCT, RCT
IT T lymphocyte subpopulations such as CD2, CD4, CD8↓ and normalized ?the ratio of CD4/CD8 [39] Non-RCT
AS Serum IL-17, PGE2, and MMP-3↓ [40] Case-control study
AS CD4+CD25+CD127low Tregs↑, IL-17↓ in blood [41] Case-control study
Psoriasis Serum IL-6, IL-17, IL-23↓ [42] Before–after study
LN Serum IL-18↓ [45] Before–after study
DKD MCP-1↓ in urine [46] Non-RCT
DKD TNF-α, CD4+ , CD4+/CD8+↓ in blood [48] RCT
RNS IL-2, TNF-α, IL-13, IL-6, IL-4↓ in blood [49] RCT
TPO RA Serum NOB, NETs↓ [22] Case-control study
TPT Asthma IL-2, IL-4, IL-5↓ from PBMCs [34] Before–after study
TwHF SLE NF-κB↓ [44] Case–control study
DKD MCP-1, CTGF, TGF-β1↓ in urine [46, 47] RCT
CGN TNF-α, IL-6↓ in blood [50] RCT
Tab.1  TwHF and its bioactive components for their targets involved in clinical immunoregulation
Fig.1  Immunoregulatory effects of TwHF and its bioactive components for their targets involved in clinical use.
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