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Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice |
Dan Luo1,2, Zhengyun Zuo3, Hongyan Zhao4, Yong Tan5, Cheng Xiao2() |
1. Traditional Chinese Medicine Hospital of Changping District, Beijing 102200, China 2. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China 3. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China 4. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100070, China 5. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100070, China |
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Abstract Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells; ratio of T cell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.
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Keywords
Tripterygium wilfordii Hook F
immunoregulation
clinical studies
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Corresponding Author(s):
Cheng Xiao
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Just Accepted Date: 16 November 2018
Online First Date: 02 January 2019
Issue Date: 14 October 2019
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1 |
X Wang, Y Zu, L Huang, J Yu, H Zhao, C Wen, Z Chen, Z Xu. Treatment of rheumatoid arthritis with combination of methotrexate and Tripterygium wilfordii: a meta-analysis. Life Sci 2017; 171: 45–50
https://doi.org/10.1016/j.lfs.2017.01.004
pmid: 28088452
|
2 |
T Patavino, DM Brady. Natural medicine and nutritional therapy as an alternative treatment in systemic lupus erythematosus. Altern Med Rev 2001; 6(5): 460–471
pmid: 11703166
|
3 |
SJ Mao, XM Huang. Tripterygium wilfordii Hook F is efficacious in the treatment of Henoch-Schönlein purpura nephritis in children. World J Pediatr 2016; 12(3): 375–376
https://doi.org/10.1007/s12519-016-0032-z
pmid: 27351576
|
4 |
C Zhang, PP Sun, HT Guo, Y Liu, J Li, XJ He, AP Lu. Corrigendum: Safety profiles of Tripterygium wilfordii Hook F: a systematic review and meta-analysis. Front Pharmacol 2017; 8: 59
pmid: 28217100
|
5 |
F Chen, YL Ma, H Ding, BP Chen. Effects of Tripterygium wilfordii glycosides on regulatory T cells and Th17 in an IgA nephropathy rat model. Genet Mol Res 2015; 14(4): 14900–14907
https://doi.org/10.4238/2015.November.18.55
pmid: 26600551
|
6 |
P Chen, R Han, Q Zhou, H Cheng, K Zhu. Modulatory effect of triptolide on differentiation of human Th17 cells. Chin J Chin Mater Med (Zhongguo Zhong Yao Za Zhi) 2011; 36(11): 1499–1502 (in Chinese)
pmid: 22779186
|
7 |
YH Yan, PZ Shang, QJ Lu, X Wu. Triptolide regulates T cell-mediated immunity via induction of CD11clow dendritic cell differentiation. Food Chem Toxicol 2012; 50(7): 2560–2564
https://doi.org/10.1016/j.fct.2012.04.033
pmid: 22561680
|
8 |
X Tao, LS Davis, PE Lipsky. Effect of an extract of the Chinese herbal remedy Tripterygium wilfordii Hook F on human immune responsiveness. Arthritis Rheum 1991; 34(10): 1274–1281
https://doi.org/10.1002/art.1780341011
pmid: 1930317
|
9 |
AM Brinker, J Ma, PE Lipsky, I Raskin. Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 2007; 68(6): 732–766
https://doi.org/10.1016/j.phytochem.2006.11.029
pmid: 17250858
|
10 |
Y Zhou, Y Hong, H Huang. Triptolide attenuates inflammatory response in membranous glomerulo-nephritis rat via downregulation of NF-kB signaling pathway. Kidney Blood Press Res 2016; 41(6): 901–910
https://doi.org/10.1159/000452591
pmid: PMID:27871079
|
11 |
AA Abdin, EA Hasby. Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats. Eur J Pharmacol 2014; 742: 102–112
https://doi.org/10.1016/j.ejphar.2014.09.001
pmid: 25218987
|
12 |
RL Li, PL Liu, XC Wu. Clinical and experimental study on sustained release tablet of Tripterygium wilfordii in treating rheumatoid arthritis. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 1996; 16(1): 10–13 (in Chinese)
pmid: PMID:8732122
|
13 |
LL Li. Effects of Tripterygium wilfordii polyglycoside on plasma TNF-α and IL-6 in patients with rheumatoid arthritis. Acta Acad Med Guangxi (Guangxi Yi Ke Da Xue Xue Bao) 2005; 22(5): 33–35 (in Chinese)
|
14 |
R Goldbach-Mansky, M Wilson, R Fleischmann, N Olsen, J Silverfield, P Kempf, A Kivitz, Y Sherrer, F Pucino, G Csako, R Costello, TH Pham, C Snyder, D van der Heijde, X Tao, R Wesley, PE Lipsky. Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. Ann Intern Med 2009; 151(4): 229–240, W49–51
|
15 |
J Min, YP Jing, ZH Gu. Effects of Tripterygium wilfordii polyglycoside combined with leflunomide on elderly rheumatoid arthritis and interleukin-1, interleukin-6 and tumor necrosis factor-α. Pharmacol Clin Chin Mater Clin Med (Zhong Yao Yao Li Yu Lin Chuang) 2013; 29(3): 185–186 (in Chinese)
|
16 |
YX Cui, L Yang. Effects of Tripterygium wilfordii polyglycoside combined with leflunomide on C-reactive protein, interleukin-10, soluble cell adhesion molecule 1 levels of elderly patients with active rheumatoid arthritis. Chin J Gerontol (Zhongguo Lao Nian Xue Za zhi) 2016; 36(19): 4878–4880 (in Chinese)
|
17 |
YJ Li, T Zhang, XF Zhu, JX Tu, Y Jin, XR Xia. Clinical analysis of Tripterygium wilfordii polyglycoside combined with tocilizumab in the treatment of rheumatoid arthritis. Chin Med Mat (Zhong Yao Cai) 2015; 38(8): 1775–1777 (in Chinese)
|
18 |
AP Peng, XY Wang, JH Zhuang. Effect of triptolide on COX2/PGE2 axis to inhibit Th17 cell differentiation. Chin J Chin Mater Med (Zhongguo Zhong Yao Za Zhi) 2014, 39(3): 536–539 (in Chinese)
|
19 |
A Elmesmari, AR Fraser, C Wood, D Gilchrist, D Vaughan, L Stewart, C McSharry, IB McInnes, M Kurowska-Stolarska. MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in rheumatoid arthritis. Rheumatology (Oxford) 2016; 55(11): 2056–2065
https://doi.org/10.1093/rheumatology/kew272
pmid: 27411480
|
20 |
A Peng, X Huang, R Liu, X Wang, J Zhuang. Triptolide inhibits the inflammatory response of monocytes from rheumatoid arthritis patients by regulating miR-155. Cell Mol Immunol (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi) 2014; 30(6): 635–638 (in Chinese)
pmid: 24909288
|
21 |
Y Yang, Y Ye, Q Qiu, Y Xiao, M Huang, M Shi, L Liang, X Yang, H Xu. Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway. Int Immunopharmacol 2016; 41: 8–16
https://doi.org/10.1016/j.intimp.2016.10.005
pmid: 27816728
|
22 |
Y Yu, CD Koehn, Y Yue, S Li, GM Thiele, MP Hearth-Holmes, TR Mikuls, JR O’Dell, LW Klassen, Z Zhang, K Su. Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation. Curr Mol Med 2015; 15(4): 401–410
https://doi.org/10.2174/1566524015666150505160743
pmid: 25941817
|
23 |
MH Yang, FX Wu, CM Xie, YF Qing, GR Wang, XL Guo, Z Tang, JG Zhou, GH Yuan. Expression of CC chemokine ligand 5 in patients with rheumatoid arthritis and its correlation with disease activity and medication. Chin Med Sci J 2009; 24(1): 50–54
https://doi.org/10.1016/S1001-9294(09)60059-6
pmid: 19382425
|
24 |
W Li, X Wang, J Li, M Liu, J Feng. A study of immunocyte subsets and serum cytokine profiles before and after immunal suppression treatment in patients with immune thrombocytopenia. Chin J Intern Med (Zhonghua Nei Ke Za Zhi) 2016; 55(2): 111–115 (in Chinese)
pmid: 26875579
|
25 |
XQ Yu, HM Chen, JH Sun, M Luo, YL Lu. Therapeutic efficacy of multigly-cosidorum Tripterygium combined with rhIL-11 for immune thrombocytopenia. J Exp Hematol (Zhongguo Shi Yan Xue Ye Xue Za Zhi) 2015; 23(5): 1400–1403 (in Chinese)
pmid: 26524046
|
26 |
J Shen, Z Li, W Li, Y Ge, M Xie, M Lv, Y Fan, Z Chen, D Zhao, Y. Han Th1, Th2, and Th17 cytokine involvement in thyroid associated ophthalmopathy. Dis Markers 2015; 2015: 609593
|
27 |
JP Xu, JP Xu, C Xu, J Chen, ZH Jin, HF Zheng, J Zhu. Peripheral blood cell factors of Graves ophthalmopathy and effect of intervention with Tripterygium glycosides. Chin J Chin Mater Med (Zhongguo Zhong Yao Za Zhi) 2014; 39(3): 544–547 (in Chinese)
pmid: 24946565
|
28 |
SX Yan, Y Wang. Inhibitory effects of triptolide on interferon-γ-induced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retro-ocular fibroblasts derived from patients with Graves’ ophthalmopathy. Clin Experiment Ophthalmol 2006; 34(3): 265–271
https://doi.org/10.1111/j.1442-9071.2006.01190.x
pmid: 16671908
|
29 |
QS Huang, ZL Zhang, YM Liu. Effect of Tripterygium wilfordii polyglycoside on serum IL-2 and TNF-α in patients with acute anterior U-veitis. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 2002; 22(6): 432–434 (in Chinese)
pmid: 12585188
|
30 |
G Li, J Ren, G Wang, G Gu, D Hu, H Ren, Z Hong, X Wu, S Liu, J Li. T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn’s disease. Int Immunopharmacol 2014; 18(2): 244–248
https://doi.org/10.1016/j.intimp.2013.12.014
pmid: 24369313
|
31 |
J Ren, Q Tao, X Wang, Z Wang, J Li. Efficacy of T2 in active Crohn’s disease: a prospective study report. Dig Dis Sci 2007; 52(8): 1790–1797
https://doi.org/10.1007/s10620-007-9747-y
pmid: 17410440
|
32 |
ZX Li, H Tan, XJ Xiong. Clinical effect of Tripterygiitotorum combined with prednisone and its effect on serum IL-6 level in treating patients with myasthenia gravis. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 2002; 22(3): 175–177 (in Chinese)
pmid: 12585099
|
33 |
XH Wang, ZY Zhang. Effect of Tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 2001; 21(1): 25–27 (in Chinese)
pmid: 12577372
|
34 |
KX Lin, CZ Wang, GS Qian. Effect of Tripterygium wilfordii on Th1, Th2 cytokines production in asthma patients. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 2001; 21(1): 22–24 (in Chinese)
pmid: 12577371
|
35 |
JY Xu, FX Jiang, YJ Qiu. Effects of Tripterygium polyglucosideo (TP) on cytokines and eosinophil apoptosis in asthmatic patients in sputum. Chin J Microbiol Immunol (Zhong hua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi) 2004; 24(2): 57–59 (in Chinese)
|
36 |
QJ Shen, LM Wang, JH Wang, YP Xu, LJ Zhu. Modulatory effect of glucosidorum Tripterygii tororum (GTT) on TH1/TH2 cytokine balance state of asthmatic patients. Chin J Microbiol Immunol (Zhong hua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi) 2002; 22(3): 96–98 (in Chinese)
|
37 |
X Zhang, J Xia, H Ye. Effect of Tripterygium polyglycoside on interleukin-6 in patients with Guillain-Barre syndrome. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 2000; 20(5): 332–334(in Chinese)
pmid: 11789240
|
38 |
X Zhang, JH Xia, HH Ye. Effect of Tripterygium wilfordii polyglycoside on IL-6 and sIL-2R in serum and cerebrospinal fluid of patients with Guillain-Barré syndrome. Chin J Immunol (Zhongguo Mian Yi Xue Za Zhi) 2001; 17(1): 53–54 (in Chinese)
|
39 |
XZ Zhang, S Li, XZ Wu. Effects of Tripterygiitotorum in the treatment of insulin dependent diabetes mellitus with islet transplantation. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 1994; 14(8): 451–453 (in Chinese)
pmid: 7841749
|
40 |
W Ji, Y Chen, X Zhao, Y Guo, L Zhong, H Li, D Wang, Y Song. Beneficial effects of Tripterygium glycosides tablet on biomarkers in patients with ankylosing spondylitis. Mol Med Rep 2015; 12(1): 684–690
https://doi.org/10.3892/mmr.2015.3448
pmid: 25760304
|
41 |
W Ji, H Li, F Gao, Y Chen, L Zhong, D Wang. Effects of Tripterygium glycosides on interleukin-17 and CD4+CD25+ CD127low regulatory T-cell expression in the peripheral blood of patients with ankylosing spondylitis. Biomed Rep 2014; 2(4): 517–520
https://doi.org/10.3892/br.2014.262
pmid: 24944799
|
42 |
SH Lan, J Ye, X Zou, HZ Wang, LJ Zhao. Effect of Tripterygium wilfordii on serum levels of IL-6, IL-17 and IL-23 in patients with psoriasis vulgaris. J Clin Dermatol (Lin Chuang Pi Fu Ke Za Zhi) 2017; 46(12): 877–879 (in Chinese)
|
43 |
T Li, J Xie, Y Li, JP Routy, Y Li, Y Han, Z Qiu, W Lv, X Song, M Sun, X Zhang, F Wang, H Jiang. Tripterygium wilfordii Hook F extract in cART-treated HIV patients with poor immune response: a pilot study to assess its immunomodulatory effects and safety. HIV Clin Trials 2015; 16(2): 49–56
https://doi.org/10.1179/1528433614Z.0000000005
pmid: 25874991
|
44 |
XB Peng, N Wang, K Zeng. Effect of Tripterygium wilforddi Hook on the expression of nuclear factor-kB in peripheral blood mononuclear cells in patients with systemic lupus erythematosus. Chin J Derm Venereol (Zhongguo Pi Fu Xing Bing Xue Za Zhi) 2006; 20(6): 336–337 (in Chinese)
|
45 |
CY Jin, GH Hu, BZ Zheng, DL Wang. Study on effect of Tripterygium on plasma IL-18 content in patients with lupus nephritis. Chin J Chin Mater Med (Zhongguo Zhong Yao Za Zhi) 2008; 33(9): 1075–1077 (in Chinese)
pmid: 18652362
|
46 |
HX Song, J Gong, W Chen. Effect of triptolide on urinary monocyte chemoattractant protein-1 in patients with diabetic nephropathy. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 2005; 25(5): 416–418 (in Chinese)
pmid: 15957833
|
47 |
R Ma, Y Xu, W Jiang, W Zhang. Combination of Tripterygium wilfordii Hook F and angiotensin receptor blocker synergistically reduces excretion of urinary podocytes in patients with type 2 diabetic kidney disease. Biotechnol Biotechnol Equip 2015; 29(1): 139–146
https://doi.org/10.1080/13102818.2014.989727
pmid: 26019627
|
48 |
GB Xu, DJ Chen, WZ Chen. Effect of Tripterygium wilfordii polyglycoside on inflammatory factor level in patients with diabetic nephropathy. Chin Arch J Tradit Chin Med (Zhonghua Zhong Yi Yao Xue Kan) 2017; 35(8): 2206–2208 (in Chinese)
|
49 |
GH Hu, ZW Yi, JH Wang, JC Yao. Effect of Triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child recurrent nephrotic syndrome. Chin J Chin Mater Med (Zhongguo Zhong Yao Za Zhi) 2008; 33(4): 441–443 (in Chinese)
pmid: 18533507
|
50 |
WY Pei, CH Yang, XL Zhang. Effects and mechanism of Tripterygium wilfordii on chronic glomerulo nephritis. Genet Mol Res 2016; 15(1): 1–7
https://doi.org/10.4238/gmr.15017410
pmid: 26909960
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