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A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications |
Xiaolin Fan, Yanzhen Xiong, Yuan Wang() |
Department of Neurology and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China |
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Abstract Glioblastoma (GBM) is the most common and lethal primary neoplasm in the central nervous system. Despite intensive treatment, the prognosis for patients with GBM remains poor, with a median survival of 14--16 months. 90% of GBMs are primary GBMs that are full-blown at diagnosis without evidences of a pre-existing less-malignant precursor lesion. Therefore, identification of the cell(s) of origin for GBM---the normal cell or cell type that acquires the initial GBM-promoting genetic hit(s)---is the key to the understanding of the disease etiology and the development of novel therapies. Neural stem cells and oligodendrocyte precursor cells are the two major candidates for the cell(s) of origin for GBM. Latest data from human samples have reignited the longstanding debate over which cells are the clinically more relevant origin for GBMs. By critically analyzing evidences for or against the candidacy of each cell type, we highlight the most recent progress and debate in the field, explore the clinical implications, and propose future directions toward early diagnosis and preventive treatment of GBMs.
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Keywords
glioblastoma
cell(s) of origin
neural stem cells
oligodendrocyte precursor cells
subventricular zone
early diagnosis
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Corresponding Author(s):
Yuan Wang
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Just Accepted Date: 13 June 2019
Online First Date: 19 July 2019
Issue Date: 14 October 2019
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