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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.
REVIEW
The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes
Honglu Zhou1, Songmei Wang2, Lorenz von Seidlein3,4, Xuanyi Wang1,5()
1. Key Laboratory of Medical Molecular Virology of MoE & MoH, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
2. Laboratory of Molecular Biology, Training Center of Medical Experiments, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
3. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
4. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX1 2JD, UK
5. Children’s Hospital, Fudan University, Shanghai 200032, China
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Abstract

With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children<2 years and elderly≥65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.

Keywords molecular epidemiology      norovirus      disease burden      genotype      China     
Corresponding Authors: Xuanyi Wang   
Just Accepted Date: 19 November 2019   Online First Date: 11 December 2019   
 Cite this article:   
Honglu Zhou,Songmei Wang,Lorenz von Seidlein, et al. The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes[J]. Front. Med., 11 December 2019. [Epub ahead of print] doi: 10.1007/s11684-019-0733-5.
 URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-019-0733-5
http://academic.hep.com.cn/fmd/EN/Y/V/I/0
Genotype Sources of data and study design
GenBank
(hospital-based and outbreaks surveys)
(%)
Meta-analysis
(hospital-based surveys)
(%)
Zhengding
(population-based surveillance)
(%)
Sanjiang
(population-based surveillance)
(%)
GI.1 1.6 0.6
GI.2 3.4 2.3
GI.3 2.2 1.7
GI.4 1.4 1.8 0.6
GI.5 2.1 1.4
GI.6 0.7 1.3
GI.7 0.1 1.3
GI.8 0.8 0.8
GI.9 0.2 1.6
GII.1 0.1 2.8
GII.2 0.9 0.8 7.5
GII.3 7.7 9.5 32.5
GII.4 50.1 49.7 30.0 37.7
GII.5 0.1 2.4
GII.6 3.2 1.5 2.5 39.3
GII.7 0.7 0.4 0.6 4.9
GII.8 0.03 0.5
GII.10 0.8
GII.11 1.7
GII.12 3.4 2.4
GII.13 1.2 1.7
GII.14 0.2 0.4
GII.15 0.1 0.6
GII.16 0.1 0.5
GII.17 10.9 8.4 3.3
GII.18 0.6
GII.21 1.2 0.4
GII.22 0.03 0.8
Others 7.46 2.8 26.3 13.1
Tab.1  Genotypes distribution of norovirus by study design in China
Fig.1  The detection rates of norovirus from different sources by seasonality.
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