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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2020, Vol. 14 Issue (2) : 193-198    https://doi.org/10.1007/s11684-020-0772-y
RESEARCH ARTICLE
Clinical characteristics of 19 neonates born to mothers with COVID-19
Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong()
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract

The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed data of mothers and infants. There are 19 neonates included in the research. Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 mothers were clinically diagnosed with COVID-19. Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days. No fetal distress was found. Gestational age of the neonates was 38.6±1.5 weeks, and average birth weight was 3293±425 g. SARS-CoV-2 RT-PCR in throat swab, urine, and feces of all neonates were negative. SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too. None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study. The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.

Keywords coronavirus disease 2019      severe acute respiratory syndrome-associated coronavirus      maternal-infant infection      newborn     
Corresponding Author(s): Zhihui Rong   
Just Accepted Date: 19 March 2020   Online First Date: 09 April 2020    Issue Date: 09 May 2020
 Cite this article:   
Wei Liu,Jing Wang,Wenbin Li, et al. Clinical characteristics of 19 neonates born to mothers with COVID-19[J]. Front. Med., 2020, 14(2): 193-198.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-020-0772-y
https://academic.hep.com.cn/fmd/EN/Y2020/V14/I2/193
Fig.1  Chest CT scan in 2 pregnant women. Case 10: Decreased diffuse and bilateral ground-glass opacities, patchy lung consolidation, and blurred borders are shown in the four layers of the chest CT images. Case 11: Patchy lung consolidation and lesions merged into strips are shown in the four layers of the left lung.
Case ?No. Throat swab for ?SARS-CoV-2 Age? (year) Gestational ?age (week) Fever Cough Diarrhea Time between ?symptoms ?and delivery Antiviral treat-?ment before ?delivery
1 + 36 36+3 Yes No No 21 days No
2 + 26 35+2 Yes Yes No 9 days Yes
3 + 38 38+2 Yes Yes No 7 days Yes
4 + 34 40 Yes No No 8 hours No
5 + 31 41+2 Yes No No 12 days Yes
6 + 34 38+4 Yes No No 7 days No
7 + 30 39+5 No Yes No 10 days Yes
8 + 33 38+2 No No Yes 32 hours No
9 + 34 38+2 Yes No No 4 days No
10 + 33 37+2 No Yes No 21 days Yes
11 27 39+5 Yes No No 4 days Yes
12 30 39+1 No No No No
13 26 37+5 No No Yes 2 days No
14 30 38+6 Yes No No 1 day No
15 27 41+2 No No No No
16 26 39 No No No No
17 30 38 Yes No No 1 day No
18 33 39 Yes Yes No 2 days No
19 33 38 No No No No
Tab.1  Maternal characteristics
Case ?No. Birth ?weight (g) White blood cell ?(×109 cells/L) Lymphocytes ?(×109 cells/L) Neutrophil ?(×109 cells/L) Platelets ?(×109 cells/L) C-reactive protein ?(g/L) Alanine ?transaminase ?(IU/L) Aspartate ?transaminase ?(IU/L) Urea ?(mmol/L) Creatinine ?(μmol/L)
1 2840 11.9 2.41 6.91 301 2.2 7 31 3.7 65
2 2500 15.46 4.29 8.23 154 4.2 10 40 2.3 68
3 2920 16.53 3.68 11.41 260 2.2 29 87 2.5 72
4 3250 12.1 7.4 4.2 224 0.1 14 52 1.93 58
5 3470 9.99 2.22 5.99 114 0.2 27 64 1.6 69
6 3250 22.19 3.31 16.4 137 0.1 18 28 1.6 66
7 3670 18 3.8 11.7 208 1.2 24 150 2.1 66
8 3180 10.66 4.01 4.91 342 0.1 6 29 1.64 47
9 3200 13.3 6.34 5.8 289 0.2 10 35 2.5 60
10 3300 16.19 6.34 8.23 312 0.3 15 26 1.5 55
11 3190 8.91 1.9 5.49 299 2.2 8 61 4 84
12 3290 12.44 3.33 7.93 295 1.4 54 340 3.7 56
13 2640 20.66 3.03 14.91 266 0.1 5 25 3.4 82
14 3710 16.88 2.22 13.51 362 9.2 9 54 3.7 62
15 4120 16.14 4.34 10.84 242 2.8 7 35 2.1 87
16 3160 20.9 2.67 16.21 300 10.8 11 70 4.3 78
17 3860 16.48 3.43 11.15 369 0.5 6 26 4.2 67
18 3930 30.43 5.43 21.52 307 1.1 15 89 5.2 95
19 3090 18.37 4.75 11.93 295 3.7 7 38 2.2 82
Median (P25–P75) 16.19 (12.1–18.37) 3.8 (3.03–4.75) 10.84 (5.99–13.51) 295 (224–312) 1.2 (0.2–3.7) 10 (7–18) 40 (29–70) 2.5 (1.93–3.7) 67 (60–78)
Mean±SD 3293±425                  
Tab.2  Clinical characteristics of neonates
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